Cardiovascular disease is the primary cause of morbidity and mortality among the diabetic
population. Both experimental and clinical evidence suggest that diabetic subjects are …

Emerging data establish dyslipidemia as a significant contributor to the development of
diabetic neuropathy. In this review, we discuss how separate metabolic imbalances …

Reactive oxygen species (ROS), often also referred to as free radicals, play an important
role in aging. It is widely assumed that mitochondria are the predominant source of ROS …

The role of the renin-angiotensin-aldosterone system (RAAS) in many cardiovascular
disorders, including hypertension, cardiac hypertrophy, and atherosclerosis, is well …

The hypoxic areas of solid cancers represent a negative prognostic factor irrespective of
which treatment modality is chosen for the patient. Still, after almost 80 years of focus on the …

Pathological stress from cardiovascular disease stimulates hypertrophy of heart cells, which
increases the risk of cardiac morbidity and mortality. Recent evidence has indicated that …

Duchenne muscular dystrophy (DMD) is caused by deficiency of the cytoskeletal protein
dystrophin. Oxidative stress is thought to contribute to the skeletal muscle damage in DMD; …

Diabetic patients are predisposed to diabetic cardiomyopathy, a specific form of
cardiomyopathy which is characterized by the development of myocardial fibrosis …

Abstract The Hace1-HECT E3 ligase is a tumor suppressor that ubiquitylates the activated
GTP-bound form of the Rho family GTPase Rac1, leading to Rac1 proteasomal degradation …

The toxic effects of oxidative stress on cells (including cardiac myocytes, the contractile cells
of the heart) are well known. However, an increasing body of evidence has suggested that …