Sepsis was first described by the ancient Greek physicians over 2000 years ago. The
pathophysiology of the disease, however, is still not fully understood and hence the mortality …

Sepsis is a syndrome characterized by life-threatening organ dysfunction caused by the
dysregulated host response to an infection. Sepsis, especially septic shock and multiple …

Aims Sleep deprivation (SD) correlates with exacerbated systemic inflammation after sepsis.
However, the underlying mechanisms remain unclear. This study aimed to evaluate the …

Alzheimer's disease (AD) accounts for most dementia cases, but we lack a complete
understanding of the mechanisms responsible for the core pathology associated with the …

The role of the spleen in sepsis is still controversial. Therefore, we investigated the effect of
the spleen on sepsis-induced immune dysfunction in C57BL/6 mice subjected to caecal …

Aim Immunosenescence is the decline of the host immune system due to aging, resulting in
various complications. The splenic lymphoid nodule is the pivotal compartment involved in …

Sepsis-associated acute kidney injury (SA-AKI) is a common complication in critically ill
patients with high morbidity and mortality. SA-AKI varies considerably in disease …

Background Sepsis is considered an intractable dysfunction that results from the disordered
host immune response to uncontrolled infection. Even though the precise mechanism of …

Frailty is a geriatric syndrome characterized by age-related declines in function and reserve
resulting in increased vulnerability to stressors. The most consistent laboratory finding in frail …

Background and purpose Intracerebral hemorrhage (ICH) patients frequently encounter
cardiovascular complications which may contribute to increased mortality and poor long …