Voltage-dependent K+, Ca2+, and Na+ channels play vital roles in basic physiological
processes, including management of the action potential, signal transduction, and secretion …

Ca 2+ influx through voltage-gated channels initiates the exocytotic fusion of synaptic
vesicles to the plasma membrane. Here we show that RIM binding proteins (RBPs), which …

TCR stimulation triggers Ca2+ signals that are critical for T cell function and immunity.
Several pore-forming α and auxiliary β subunits of voltage-gated Ca2+ channels (VGCC) …

The nervous system has a highly complex organization, including many cell types with
multiple functions, with an intricate anatomy and unique structural and functional …

The molecular organization of presynaptic active zones is important for the neurotransmitter
release that is triggered by depolarization-induced Ca2+ influx. Here, we demonstrate a …

Cellular responses to hypoxia can be acute or chronic. Acute responses mainly depend on
oxygen-sensitive ion channels, whereas chronic responses rely on the hypoxia-inducible …

The ion Ca 2+ has been shown to play an important role in a wide variety of cellular
functions, one of them being related to cell differentiation in which nerve growth factor (NGF) …

Voltage-gated Ca2+ (CaV) channels enable Ca2+ influx in response to membrane
depolarization. CaV2. 1 channels are localized to the presynaptic membrane of many types …

Ion channels are integral membrane proteins that are critical for neuronal function. They
form pores in the plasma membrane that allow certain ions to travel with their concentration …

Null mutations in the IL1-receptor accessory protein-like 1 gene (IL1RAPL1) are responsible
for an inherited X-linked form of cognitive impairment. IL1RAPL1 protein physically interacts …