Biology and therapeutic targeting of vascular endothelial growth factor A

L Pérez-Gutiérrez, N Ferrara - Nature Reviews Molecular Cell Biology, 2023 - nature.com
The formation of new blood vessels, called angiogenesis, is an essential pathophysiological
process in which several families of regulators have been implicated. Among these, vascular …

[HTML][HTML] The role of endothelial cell–pericyte interactions in vascularization and diseases

G Li, J Gao, P Ding, Y Gao - Journal of Advanced Research, 2025 - Elsevier
Abstract Background Endothelial cells (ECs) and pericytes (PCs) are crucial components of
the vascular system, with ECs lining the inner layer of blood vessels and PCs surrounding …

Crosstalk between the nervous system and tumor microenvironment: functional aspects and potential therapeutic strategies

L Wang, J Ge, H Han, Y Jia, Y Qin - Cancer Letters, 2024 - Elsevier
Recent advancements in understanding the tumor microenvironment (TME) have
highlighted the critical role of the nervous system in cancer progression. This review …

From sweat to hope: The role of exercise‐induced extracellular vesicles in cancer prevention and treatment

A Llorente, A Brokāne, A Mlynska… - Journal of …, 2024 - Wiley Online Library
The benefits of regular physical exercise on cancer prevention, as well as reducing fatigue,
treatment side effects and recurrence, and improving quality of life and overall survival of …

VEGF signaling: Role in angiogenesis and beyond

P Shaw, SKD Dwivedi, R Bhattacharya… - … et Biophysica Acta (BBA …, 2024 - Elsevier
Angiogenesis is a crucial process for tissue development, repair, and tumor survival.
Vascular endothelial growth factor (VEGF) is a key driver secreted by cancer cells …

Pharmacological interventions for intraplaque neovascularization in atherosclerosis

A Ugusman, NSN Hisam, NS Othman… - Pharmacology & …, 2024 - Elsevier
Advanced atherosclerosis is linked to plaque instability, which can result in rupture and the
onset of a heart attack. Evidence gathered from human atheroma plaques indicates that …

Endometrial Angiogenesis of Abnormal Uterine Bleeding and Infertility in Patients with Uterine Fibroids—A Systematic Review

EE Don, MA Middelkoop, WJK Hehenkamp… - International journal of …, 2023 - mdpi.com
Uterine fibroids are the most common benign tumors in women, with abnormal uterine
bleeding (AUB) as the main reported symptom. Additionally, an association between fibroids …

Hypoxia as a potential inducer of immune tolerance, tumor plasticity and a driver of tumor mutational burden: Impact on cancer immunotherapy

R Abou Khouzam, B Janji, J Thiery, RF Zaarour… - Seminars in Cancer …, 2023 - Elsevier
In cancer patients, immune cells are often functionally compromised due to the
immunosuppressive features of the tumor microenvironment (TME) which contribute to the …

Biomarkers of endometriosis

A Pant, K Moar, TK Arora, PK Maurya - Clinica chimica acta, 2023 - Elsevier
Endometriosis is one of the most severe female reproductive disorders, affecting 6–10% of
women between 18 and 35. It is a gynaecological condition where endometrial tissue …

VEGF-A plasma levels are associated with impaired DLCO and radiological sequelae in long COVID patients

A Philippe, S Günther, J Rancic, P Cavagna, B Renaud… - Angiogenesis, 2024 - Springer
Background Long COVID, also known as post-acute sequelae of COVID-19 (PASC), is
characterized by persistent clinical symptoms following COVID-19. Objective To correlate …