The absolute reliance of the mammalian brain on oxygen to generate ATP renders it acutely
vulnerable to hypoxia, whether at high altitude or in clinical settings of anemia or pulmonary …

Globally, about 400 million people reside at terrestrial altitudes above 1500 m, and more
than 100 million lowlanders visit mountainous areas above 2500 m annually. The …

Key points Brachial artery (BA) shear‐mediated dilatation is a widely used assessment of
vascular function with links to coronary artery health and cardiovascular risk. Cerebral …

Few minutes of hypoxic exposure stabilizes hypoxia-inducible factor-1α, resulting in
erythropoietin (EPO) gene transcription and production. The objective of this study was to …

Cerebrovascular microcirculation is essential for maintaining the physiological functions of
the brain. The brain can be protected from stress injury by remodeling the microcirculation …

This study aimed to elucidate the effects of change in estrogen during the menstrual cycle
and menopause on shear-mediated dilation of the internal carotid artery (ICA), a potential …

Ischemic stroke (IS) is the leading cause of disability and death worldwide. Owing to the
aging population and unhealthy lifestyles, the incidence of cerebrovascular disease is high …

Sustained exercise-induced elevations in shear rate (SR) have been well established as
beneficial for improving endothelial function. However, the impact of intermittent fluctuations …

Sudden blood flow restoration to an ischemic vessel paradoxically damages endothelial
cells. Ischemic preconditioning, caused by repeated bouts of brief ischemia using local or …

Eight 4-min cycles of intermittent hypoxia represent the shortest hypoxic exposure to
increase erythropoietin (EPO) levels in young adults. The impact of aging on the EPO …