Nitric oxide (NO) is an important signaling molecule that is involved in a wide range of
physiological and pathological events in biology. Metal coordination chemistry, especially …

Reactive oxygen species (ROS) are subcellular messengers in signal transductions
pathways with both beneficial and deleterious roles. ROS are generated as a by-product of …

An association between arteriosclerosis and homocysteine (Hcy) was first demonstrated in
1969. Hcy is a sulfur containing amino acid derived from the essential amino acid …

Aging, hypertension, diabetes, hypoxia/obstructive sleep apnea (OSA), obesity, vitamin
B12/folate deficiency, depression, and traumatic brain injury synergistically promote diverse …

PART I THE ENDOTHELIUM has long been viewed as an inert cellophane-like membrane
that lines the circulatory system with its primary essential function being the maintenance of …

An elevated level of total homocysteine (tHcy) in blood, denoted hyperhomocysteinemia, is
emerging as a prevalent and strong risk factor for atherosclerotic vascular disease in the …

In 1969, McCully made the clinical observation linking elevated plasma homocyst (e) ine
concentrations with vascular disease. 1 He reported autopsy evidence of extensive arterial …

▪ Abstract Homocysteine is a sulfur amino acid whose metabolism stands at the intersection
of two pathways: remethylation to methionine, which requires folate and vitamin B12 (or …

Severely elevated levels of total homocysteine (approximately millimolar) in the blood typify
the childhood disease homocystinuria, whereas modest levels (tens of micromolar) are …

Background Hyperhomocysteinemia is a putative risk factor for cardiovascular disease,
which also impairs endothelium-dependent vasodilatation. A number of other risk factors for …