Tau is a microtubule-associated protein that has a role in stabilizing neuronal microtubules
and thus in promoting axonal outgrowth. Structurally, tau is a natively unfolded protein, is …

Alzheimer's disease (AD) is characterized by progressive memory loss and cognitive
function deficits. There are two major pathological hallmarks that contribute to the …

Alzheimer's disease (AD) belongs to a group of neurodegenerative diseases collectively
designated as “tauopathies”, because they are characterized by the aggregation of …

Alzheimer disease (AD) and related tauopathies are histopathologically characterized by a
specific type of slow and progressive neurodegeneration, which involves the abnormal …

The complexity of Alzheimer's disease (AD) complicates the search for effective treatments.
While the key roles of pathologically modified proteins has occupied a central role in …

Tau phosphorylation is regulated by a balance between tau kinase and phosphatase
activities. Disruption of this equilibrium was suggested to be at the origin of abnormal tau …

Alzheimer's disease (AD) is the most common neurodegenerative disorder, characterized
pathologically by extracellular deposition of β-amyloid (Aβ) into senile plaques and …

The pathogenesis and etiology of diabetes mellitus (DM) and Alzheimer's disease (AD)
share many common cellular and molecular themes. Recently, a growing body of research …

Loss-of-function mutations in the gene encoding GBA (glucocerebrosidase, β, acid), the
enzyme deficient in the lysosomal storage disorder Gaucher disease, elevate the risk of …

PP2A is a major serine/threonine phosphatase class involved in the regulation of cell
signaling through the removal of protein phosphorylation. This class of phosphatases is …