Aging and white matter microstructure and macrostructure: a longitudinal multi-site diffusion MRI study of 1218 participants

KG Schilling, D Archer, FC Yeh, F Rheault… - Brain Structure and …, 2022 - Springer
Quantifying the microstructural and macrostructural geometrical features of the human
brain's connections is necessary for understanding normal aging and disease. Here, we …

A Multimodal Meta-Analytical Evidence of Functional and Structural Brain Abnormalities Across Alzheimer's Disease Spectrum

X Tang, Z Guo, G Chen, S Sun, S Xiao, P Chen… - Ageing Research …, 2024 - Elsevier
Background Numerous neuroimaging studies have reported that Alzheimer's disease (AD)
spectrum have been linked to alterations in intrinsic functional activity and cortical thickness …

Short superficial white matter and aging: a longitudinal multi-site study of 1293 subjects and 2711 sessions

KG Schilling, D Archer, FC Yeh, F Rheault, LY Cai… - Aging Brain, 2023 - Elsevier
It is estimated that short association fibers running immediately beneath the cortex may
make up as much as 60% of the total white matter volume. However, these have been …

Dual PET-fMRI reveals a link between neuroinflammation, amyloid binding and compensatory task-related brain activity in Alzheimer's disease

N Canário, L Jorge, R Martins, I Santana… - Communications …, 2022 - nature.com
The interplay among neuropathological mechanisms underlying Alzheimer's disease (AD),
as neuroinflammation and amyloid-beta (Aβ), as well their impact on neuronal function …

Associations between cortical β‐amyloid burden, fornix microstructure and cognitive processing of faces, places, bodies and other visual objects in early Alzheimer's …

J Bourbon‐Teles, L Jorge, N Canário, R Martins… - …, 2023 - Wiley Online Library
Using two imaging modalities, that is, Pittsburgh compound B (PiB) positron emission
tomography (PET) and diffusion tensor imaging (DTI) the present study tested associations …

Diurnal cortisol, neuroinflammation, and neuroimaging visual rating scales in memory clinic patients

J Holleman, M Daniilidou, I Kåreholt, M Aspö… - Brain, behavior, and …, 2024 - Elsevier
Background Neuroinflammation is a hallmark of the Alzheimer's disease (AD) pathogenic
process. Cortisol dysregulation may increase AD risk and is related to brain atrophy. This …

PET imaging of tau pathology and amyloid-β, and MRI for Alzheimer's disease feature fusion and multimodal classification

M Shojaie, S Tabarestani, M Cabrerizo… - Journal of …, 2021 - content.iospress.com
Background: Machine learning is a promising tool for biomarker-based diagnosis of
Alzheimer's disease (AD). Performing multimodal feature selection and studying the …

Hemispheric patterns of recruitment of object processing regions in early Alzheimer's Disease: A study along the entire ventral stream

NS Canário, LP Jorge, IJ Santana… - Journal of …, 2023 - content.iospress.com
Background: Investigation of neural response patterns along the entire network of
functionally defined object recognition ventral stream regions in Alzheimer's disease (AD) is …

Textural properties of microglial activation in Alzheimer's disease as measured by (R)-[11C]PK11195 PET

M Lapo Pais, L Jorge, R Martins, N Canário… - Brain …, 2023 - academic.oup.com
Alzheimer's disease is the most common form of dementia worldwide, accounting for 60–
70% of diagnosed cases. According to the current understanding of molecular …

In vivo molecular imaging of the neuroinflammatory response to peripheral acute bacterial infection in older patients with cognitive dysfunction: A cross-sectional …

AR Silva, P Regueira, A Peres, AL Cardoso… - Frontiers in Aging …, 2022 - frontiersin.org
Introduction Chronic neuroinflammatory events have been implicated in the pathophysiology
of neurodegenerative conditions but no studies have directly examined the …