As much as the cellular viability is important for the living organisms, the elimination of
unnecessary or damaged cells has the opposite necessity for the maintenance of …

Apoptosis is characterised by a series of typical morphological features, such as shrinkage
of the cell, fragmentation into membrane-bound apoptotic bodies and rapid phagocytosis by …

▪ Abstract Apoptosis is a genetically programmed, morphologically distinct form of cell death
that can be triggered by a variety of physiological and pathological stimuli. Studies …

Caspases play an essential role during apoptotic cell death. These enzymes define a new
class of cysteine proteases and comprise a multi-gene family with more than a dozen distinct …

Cell death is discriminated into two main forms: apoptosis and necrosis. In contrast to
necrosis, apoptosis is a regulated, energy-dependent form of cell death leading to …

Apoptotic cell death is executed by the caspase-mediated cleavage of various vital proteins.
Elucidating the consequences of this endoproteolytic cleavage is crucial for our …

NMDA receptor-dependent synaptic modifications, such as long-term potentiation (LTP) and
long-term depression (LTD), are essential for brain development and function. LTD occurs …

Apoptosis, a morphologically defined form of physiological cell death, is implemented by a
death machinery whose executionary arm is a family of cysteine proteases called caspases …

Glutamate receptor-mediated excitatory neurotransmission plays a key role in neural
development, differentiation and synaptic plasticity. However, excessive stimulation of …

Brain ischemia and reperfusion engage multiple independently-fatal terminal pathways
involving loss of membrane integrity in partitioning ions, progressive proteolysis, and …