The accurate transition from G1 phase of the cell cycle to S phase is crucial for the control of
eukaryotic cell proliferation, and its misregulation promotes oncogenesis. During G1 phase …

Mutations of the retinoblastoma tumour suppressor gene (RB1) or components regulating
the RB pathway have been identified in almost every human malignancy. The E2F …

The architecture of human chromosomes in interphase nuclei is still largely unknown.
Microscopy studies have indicated that specific regions of chromosomes are located in close …

Summary c-Myc (Myc) is an important transcriptional regulator in embryonic stem (ES) cells,
somatic cell reprogramming, and cancer. Here, we identify a Myc-centered regulatory …

Dark-grown seedlings exhibit skotomorphogenic development. Genetic and molecular
evidence indicates that a quartet of Arabidopsis Phytochrome (phy)-Interacting bHLH …

A crucial question in the field of gene regulation is whether the location at which a
transcription factor binds influences its effectiveness or the mechanism by which it regulates …

Mutations in the retinoblastoma tumor suppressor gene Rb are involved in many forms of
human cancer. In this study, we investigated the early consequences of inactivating Rb in …

Cellular senescence is a tumour-suppressor mechanism that is triggered by cancer-initiating
or promoting events in mammalian cells. The molecular underpinnings for this stable arrest …

One goal of human genetics is to understand how the information for precise and dynamic
gene expression programs is encoded in the genome. The interactions of transcription …

Using deep sequencing (deepCAGE), the FANTOM4 study measured the genome-wide
dynamics of transcription-start-site usage in the human monocytic cell line THP-1 throughout …