The interplay of inflammation and remyelination: rethinking MS treatment with a focus on oligodendrocyte progenitor cells

O Zveik, A Rechtman, T Ganz… - Molecular …, 2024 - Springer
Background Multiple sclerosis (MS) therapeutic goals have traditionally been dichotomized
into two distinct avenues: immune-modulatory-centric interventions and pro-regenerative …

Ultrahigh frequencies of peripherally matured LGI1-and CASPR2-reactive B cells characterize the cerebrospinal fluid in autoimmune encephalitis

J Theorell, R Harrison, R Williams… - Proceedings of the …, 2024 - National Acad Sciences
Intrathecal synthesis of central nervous system (CNS)-reactive autoantibodies is observed
across patients with autoimmune encephalitis (AE), who show multiple residual …

[HTML][HTML] Immunoglobulin G and Complement as Major Players in the Neurodegeneration of Multiple Sclerosis

PGE Kennedy, M Fultz, J Phares, X Yu - Biomolecules, 2024 - mdpi.com
Multiple Sclerosis (MS) is an inflammatory, demyelinating, and neurodegenerative disease
of the central nervous system (CNS) and is termed as one of the most common causes of …

High heterogeneity of cross-reactive immunoglobulins in multiple sclerosis presumes combining of B-cell epitopes for diagnostics: a case-control study

LA Ovchinnikova, IE Eliseev, SS Dzhelad… - Frontiers in …, 2024 - frontiersin.org
Background Multiple sclerosis (MS) is a neuroinflammatory disease triggered by a
combination of genetic traits and external factors. Autoimmune nature of MS is proven by the …

Self-assembled nanoparticles of rapamycin prodrugs for the treatment of multiple sclerosis

R Zhang, X Yao, Q Li, X Li, Q Ma, W Huang… - Journal of Colloid and …, 2025 - Elsevier
Optimizing the design of nanoparticulate co-delivery systems of antigens and
immunomodulators to induce antigen-specific immune tolerance effectively remains a …

[HTML][HTML] Primary Progressive Multiple Sclerosis—A Key to Understanding and Managing Disease Progression

I Sempik, E Dziadkowiak, H Moreira, A Zimny… - International Journal of …, 2024 - mdpi.com
Primary progressive multiple sclerosis (PPMS), the least frequent type of multiple sclerosis
(MS), is characterized by a specific course and clinical symptoms, and it is associated with a …

Effects of cladribine on intrathecal and peripheral B and plasma cells

K Allen-Philbey, S Stephenson, G Doody… - Clinical and …, 2025 - academic.oup.com
Introduction Cladribine is a deoxyadenosine analogue that can penetrate the blood–brain
barrier. It is used to treat multiple sclerosis (MS). However, the mechanistic understanding of …

Tolerogenic Reverse Micelle Nanovaccine Prevents Onset and Progression of Multiple Sclerosis

R Zhang, H Zhang, Y Wang, Y Hu, Q Ma… - ACS Applied Nano …, 2024 - ACS Publications
Exhilarating breakthroughs in the treatment of autoimmune diseases through antigen-
specific therapies offer new hope for patients. Herein, a novel antigen-specific reverse …

MACHINE-LEARNING TECHNIQUES IN MULTIPLE SCLEROSIS PREDICTION USING EEG

L Soleimanidoust, A Rezai, H Barghamadi… - Biomedical …, 2024 - World Scientific
The diagnosis and quantification of Multiple Sclerosis (MS) have typically depended on
skilled doctors recognizing visual patterns, such as Magnetic Resonance Imaging (MRI) and …

A distinctive IgG-mediated pathogenesis for primary progressive multiple sclerosis?

Y Guo, VA Lennon - Brain, 2023 - academic.oup.com
distinctive IgG-mediated pathogenesis for primary progressive multiple sclerosis? | Brain |
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