Type 1 diabetes mellitus (T1DM) is a growing global health concern that affects
approximately 8.5 million individuals worldwide. T1DM is characterized by an autoimmune …

Cellular therapies are poised to transform the field of medicine by restoring dysfunctional
tissues and treating various diseases in a dynamic manner not achievable by conventional …

Microencapsulation is a promising strategy to prolong the survival and function of
transplanted pancreatic islets for diabetes therapy, albeit its translation has been impeded …

Pancreatic islet transplantation efficacy for type 1 diabetes (T1D) management is limited by
hypoxia-related graft attrition and need for systemic immunosuppression. To overcome …

Islet transplantation has now become a promising treatment for insulin-deficient diabetes
mellitus. Compared to traditional diabetes treatments, cell therapy can restore endogenous …

Intrahepatic islet transplantation is a promising β-cell replacement strategy for the treatment
of type 1 diabetes. Instant blood-mediated inflammatory reactions, acute inflammatory storm …

Background Human omentum-derived mesenchymal stem cells (hO-MSCs) possess great
potential to differentiate into multiple lineages and have self-renewal capacity, allowing them …

Immunoisolation of pancreatic islets in alginate microcapsules allows for transplantation in
the absence of immunosuppression but graft survival time is still limited. This limited graft …

Challenges remain to be solved for the clinical translation of β-cell encapsulation technology
in the treatment of type 1 diabetes (T1D). Successful delivery of β cells urgently needs the …

Islet allotransplantation offers a promising cell therapy for type 1 diabetes, but challenges
such as limited donor availability and immunosuppression persist. Microencapsulation of …