Quorum-sensing regulation of antimicrobial resistance in bacteria

X Zhao, Z Yu, T Ding - Microorganisms, 2020 - mdpi.com
Quorum sensing is a cell-to-cell communication system that exists widely in the microbiome
and is related to cell density. The high-density colony population can generate a sufficient …

Natural products as platforms to overcome antibiotic resistance

SE Rossiter, MH Fletcher, WM Wuest - Chemical reviews, 2017 - ACS Publications
Natural products have served as powerful therapeutics against pathogenic bacteria since
the golden age of antibiotics of the mid-20th century. However, the increasing frequency of …

Quorum quenching: role in nature and applied developments

C Grandclément, M Tannières, S Moréra… - FEMS microbiology …, 2016 - academic.oup.com
Quorum sensing (QS) refers to the capacity of bacteria to monitor their population density
and regulate gene expression accordingly: the QS-regulated processes deal with …

Interference in bacterial quorum sensing: a biopharmaceutical perspective

B Rémy, S Mion, L Plener, M Elias… - Frontiers in …, 2018 - frontiersin.org
Numerous bacteria utilize molecular communication systems referred to as quorum sensing
(QS) to synchronize the expression of certain genes regulating, among other aspects, the …

Recent advances in anti-virulence therapeutic strategies with a focus on dismantling bacterial membrane microdomains, toxin neutralization, quorum-sensing …

O Fleitas Martínez, MH Cardoso, SM Ribeiro… - Frontiers in cellular …, 2019 - frontiersin.org
Antimicrobial resistance constitutes one of the major challenges facing humanity in the
Twenty-First century. The spread of resistant pathogens has been such that the possibility of …

Exploiting quorum sensing to confuse bacterial pathogens

B LaSarre, MJ Federle - Microbiology and molecular biology …, 2013 - Am Soc Microbiol
Cell-cell communication, or quorum sensing, is a widespread phenomenon in bacteria that
is used to coordinate gene expression among local populations. Its use by bacterial …

Synthetic microbial consortia: from systematic analysis to construction and applications

H Song, MZ Ding, XQ Jia, Q Ma, YJ Yuan - Chemical Society Reviews, 2014 - pubs.rsc.org
Synthetic biology is an emerging research field that focuses on using rational engineering
strategies to program biological systems, conferring on them new functions and behaviours …

Targeting virulence not viability in the search for future antibacterials

B Heras, MJ Scanlon, JL Martin - British journal of clinical …, 2015 - Wiley Online Library
New antibacterials need new approaches to overcome the problem of rapid antibiotic
resistance. Here we review the development of potential new antibacterial drugs that do not …

Quorum quenching revisited—from signal decays to signalling confusion

KW Hong, CL Koh, CK Sam, WF Yin, KG Chan - Sensors, 2012 - mdpi.com
In a polymicrobial community, while some bacteria are communicating with neighboring
cells (quorum sensing), others are interrupting the communication (quorum quenching), thus …

The art of antibacterial warfare: deception through interference with quorum sensing–mediated communication

G Rampioni, L Leoni, P Williams - Bioorganic Chemistry, 2014 - Elsevier
Almost a century on from the discovery of penicillin, the war against bacterial infection still
rages compounded by the emergence of strains resistant to virtually every clinically …