The process of cellular transformation has been amply studied in vitro using immortalized
cell lines. Immortalized cells never have the normal diploid karyotype, nevertheless, they …

Bladder cancer is a common disease representing the fifth most diagnosed solid tumor in
the United States. Despite this, advances in our understanding of the molecular etiology and …

Background: Cell culture models of normal urothelial cells are important for studying
differentiation, disease mechanisms and anticancer drug development. Beyond primary …

Methods and compositions for modulating the FGF effect on the sensitivity of malignant and
normal cells to anticancer agents are provided. In particular, methods and compositions for …

Purpose The differentiated superficial cells of the urothelium restrict urine flow into the
bladder wall. We have demonstrated that urothelial cells isolated from bladders of patients …

Vitronectin (VN), secreted into the bloodstream by liver hepatocytes, is known to anchor
epithelial cells to basement membranes through interactions with cell surface integrin …

The process of cellular transformation has been amply studied in vitro using immortalized
cell lines. Immortalized cells never have the normal diploid karyotype, nevertheless, they …

BK polyomavirus (BKPyV) is a small double-stranded DNA virus that is an emerging
pathogen in immunocompromised individuals. BKPyV infection is widespread in the general …

Cell culture systems with cancer-derived cell lines have long been used to study the
interaction between pathogens and their host cells. Due to reduced complexity these …