The enigma of the respiratory chain supercomplex
Respiratory chain dysfunction plays an important role in human disease and aging. It is now
well established that the individual respiratory complexes can be organized into …
well established that the individual respiratory complexes can be organized into …
[HTML][HTML] Structure and mechanism of mitochondrial electron transport chain
R Guo, J Gu, S Zong, M Wu, M Yang - Biomedical journal, 2018 - Elsevier
Respiration is one of the most vital and basic features of living organisms. In mammals,
respiration is accomplished by respiratory chain complexes located on the mitochondrial …
respiration is accomplished by respiratory chain complexes located on the mitochondrial …
Accessory subunits are integral for assembly and function of human mitochondrial complex I
DA Stroud, EE Surgenor, LE Formosa, B Reljic… - Nature, 2016 - nature.com
Complex I (NADH: ubiquinone oxidoreductase) is the first enzyme of the mitochondrial
respiratory chain and is composed of 45 subunits in humans, making it one of the largest …
respiratory chain and is composed of 45 subunits in humans, making it one of the largest …
High-intensity training induces non-stoichiometric changes in the mitochondrial proteome of human skeletal muscle without reorganisation of respiratory chain content
Mitochondrial defects are implicated in multiple diseases and aging. Exercise training is an
accessible, inexpensive therapeutic intervention that can improve mitochondrial …
accessible, inexpensive therapeutic intervention that can improve mitochondrial …
Mitochondrial respiratory complex I: structure, function and implication in human diseases
Mitochondria are ubiquitous organelles in eukaryotic cells whose primary function is to
generate energy supplies in the form of ATP through oxidative phosphorylation. As the entry …
generate energy supplies in the form of ATP through oxidative phosphorylation. As the entry …
Mitonuclear interactions: evolutionary consequences over multiple biological scales
JN Wolff, ED Ladoukakis… - … Transactions of the …, 2014 - royalsocietypublishing.org
Fundamental biological processes hinge on coordinated interactions between genes
spanning two obligate genomes—mitochondrial and nuclear. These interactions are key to …
spanning two obligate genomes—mitochondrial and nuclear. These interactions are key to …
The in-depth evaluation of suspected mitochondrial disease
Mitochondrial disease confirmation and establishment of a specific molecular diagnosis
requires extensive clinical and laboratory evaluation. Dual genome origins of mitochondrial …
requires extensive clinical and laboratory evaluation. Dual genome origins of mitochondrial …
Mitochondrial phosphatase PTPMT1 is essential for cardiolipin biosynthesis
PTPMT1 was the first protein tyrosine phosphatase found localized to the mitochondria, but
its biological function was unknown. Herein, we demonstrate that whole body deletion of …
its biological function was unknown. Herein, we demonstrate that whole body deletion of …
Analysis of the assembly profiles for mitochondrial-and nuclear-DNA-encoded subunits into complex I
Complex I of the respiratory chain is composed of at least 45 subunits that assemble
together at the mitochondrial inner membrane. Defects in human complex I result in energy …
together at the mitochondrial inner membrane. Defects in human complex I result in energy …
Biallelic mutations in MRPS34 lead to instability of the small mitoribosomal subunit and Leigh syndrome
The synthesis of all 13 mitochondrial DNA (mtDNA)-encoded protein subunits of the human
oxidative phosphorylation (OXPHOS) system is carried out by mitochondrial ribosomes …
oxidative phosphorylation (OXPHOS) system is carried out by mitochondrial ribosomes …