Primary aldosteronism is characterized by aldosterone secretion that is independent of renin
and angiotensin II and sodium status. The deleterious effects of primary aldosteronism are …

Primary aldosteronism (PA) is an endocrinopathy characterized by dysregulated
aldosterone production that occurs despite suppression of renin and angiotensin II, and that …

The normal stress response in humans is governed by the hypothalamic-pituitary-adrenal
(HPA) axis through heightened mechanisms during stress, raising blood levels of the …

GPER possesses structural and functional characteristics shared by members of the G-
protein-coupled receptor (GPCR) superfamily, the largest class of plasma membrane …

Originally described as the renal aldosterone receptor that regulates sodium homeostasis, it
is now clear that mineralocorticoid receptors (MRs) are widely expressed, including in …

Over the past decade, several studies have shown that activity of extra-renal
mineralocorticoid receptors (MR) regulates vascular tone, adipogenesis, adipose tissue …

Rationale: Resistant hypertension is a major health concern with unknown cause.
Spironolactone is an effective antihypertensive drug, especially for patients with resistant …

Primary aldosteronism used to be considered a rare cause of secondary hypertension.
However, accruing evidence indicates that primary aldosteronism is more common than …

The steroid hormone aldosterone (aldo) contributes to cardiovascular disease in animal
models and in humans. Aldo activates the mineralocorticoid receptor (MR), a hormone …

The renin angiotensin aldosterone system is a key regulator of blood pressure. Aldosterone
is the final effector of this pathway, acting predominantly via mineralocorticoid receptors …