Lung cancer immunotherapy: progress, pitfalls, and promises

A Lahiri, A Maji, PD Potdar, N Singh, P Parikh, B Bisht… - Molecular cancer, 2023 - Springer
Lung cancer is the primary cause of mortality in the United States and around the globe.
Therapeutic options for lung cancer treatment include surgery, radiation therapy …

Targeting cancer with antibody-drug conjugates: Promises and challenges

AQ Dean, S Luo, JD Twomey, B Zhang - MAbs, 2021 - Taylor & Francis
Antibody-drug conjugates (ADCs) are a rapidly expanding class of biotherapeutics that
utilize antibodies to selectively deliver cytotoxic drugs to the tumor site. As of May 2021, the …

Marine anticancer agents: An overview with a particular focus on their chemical classes

M Barreca, V Spanò, A Montalbano, M Cueto… - Marine drugs, 2020 - mdpi.com
The marine environment is a rich source of biologically active molecules for the treatment of
human diseases, especially cancer. The adaptation to unique environmental conditions led …

Antibody-drug conjugates: A promising novel therapeutic approach in lung cancer

A Desai, P Abdayem, AA Adjei, D Planchard - Lung Cancer, 2022 - Elsevier
Antibody-drug conjugates (ADCs) are rapidly establishing their place and have shown
promising preliminary data in lung cancer with impressive response rates and survival …

Therapeutic targeting of the functionally elusive TAM receptor family

YR Miao, EB Rankin, AJ Giaccia - Nature Reviews Drug Discovery, 2024 - nature.com
The TAM receptor family of TYRO3, AXL and MERTK regulates tissue and immune
homeostasis. Aberrant TAM receptor signalling has been linked to a range of diseases …

Immunotherapy and targeted therapy for lung cancer: Current status and future perspectives

B Zulfiqar, A Farooq, S Kanwal, K Asghar - Frontiers in Pharmacology, 2022 - frontiersin.org
Lung cancer has the highest incidence of morbidity and mortality throughout the globe. A
large number of patients are diagnosed with lung cancer at the later stages of the disease …

Development of marine-derived compounds for cancer therapy

W Zuo, HF Kwok - Marine drugs, 2021 - mdpi.com
Cancer has always been a threat to human health with its high morbidity and mortality rates.
Traditional therapy, including surgery, chemotherapy and radiotherapy, plays a key role in …

Acquired mechanisms of resistance to osimertinib—the next challenge

A Ríos-Hoyo, L Moliner, E Arriola - Cancers, 2022 - mdpi.com
Simple Summary Osimertinib has revolutionized the treatment of EGFR-mutated tumors. Its
current applications include the first-line setting, second-line setting, as well as the adjuvant …

The resurgence of antibody drug conjugates in cancer therapeutics: novel targets and payloads

V Boni, MR Sharma, A Patnaik - American Society of Clinical …, 2020 - ascopubs.org
Antibody drug conjugates (ADCs) are an emerging class of therapeutics that consist of a
cytotoxic agent linked covalently to an antibody, which is directed toward a specific cell …

The development of AXL inhibitors in lung cancer: recent progress and challenges

YB Sang, JH Kim, CG Kim, MH Hong, HR Kim… - Frontiers in …, 2022 - frontiersin.org
AXL, along with MER and TYRO3, is a receptor tyrosine kinase from the TAM family.
Although AXL itself is not thought to be a potent oncogenic driver, overexpression of AXL is …