Crossing the blood-brain barrier with nanoparticles

Y Zhou, Z Peng, ES Seven, RM Leblanc - Journal of controlled release, 2018 - Elsevier
The blood-brain barrier (BBB) is one of the most essential protection mechanisms in the
central nervous system (CNS). It selectively allows individual molecules such as small lipid …

Targeting the transferrin receptor for brain drug delivery

KB Johnsen, A Burkhart, LB Thomsen… - Progress in …, 2019 - Elsevier
Obtaining efficient drug delivery to the brain remains the biggest challenge for the
development of therapeutics to treat diseases of the central nervous system. The main …

Functionalizing nanoparticles with biological molecules: developing chemistries that facilitate nanotechnology

KE Sapsford, WR Algar, L Berti, KB Gemmill… - Chemical …, 2013 - ACS Publications
Bionanotechnology has now become firmly established in its own right as one of the
principle and focused subdisciplines within nanotechnology.(1-10) Bionanotechnology can …

Nanoparticles for brain drug delivery

M Masserini - International Scholarly Research Notices, 2013 - Wiley Online Library
The central nervous system, one of the most delicate microenvironments of the body, is
protected by the blood‐brain barrier (BBB) regulating its homeostasis. BBB is a highly …

[HTML][HTML] Advances in developing therapeutic strategies for Alzheimer's disease

TT Nguyen, TTD Nguyen, TKO Nguyen, TK Vo - Biomedicine & …, 2021 - Elsevier
Alzheimer's disease (AD) is a progressive deterioration of brain function, initially
characterized by cognitive deficits, with loss of recent memory and language ability …

Targeting the blood-brain barrier for the delivery of stroke therapies

A D'Souza, KM Dave, RA Stetler… - Advanced drug delivery …, 2021 - Elsevier
A variety of neuroprotectants have shown promise in treating ischemic stroke, yet their
delivery to the brain remains a challenge. The endothelial cells lining the blood-brain barrier …

Lipid-based colloidal carriers for peptide and protein delivery–liposomes versus lipid nanoparticles

S Martins, B Sarmento, DC Ferreira… - International journal of …, 2007 - Taylor & Francis
This paper highlights the importance of lipid-based colloidal carriers and their
pharmaceutical implications in the delivery of peptides and proteins for oral and parenteral …

Polymeric protein delivery systems

KY Lee, SH Yuk - Progress in polymer science, 2007 - Elsevier
Although various peptide and protein drugs have been developed for therapeutic purposes,
several challenges can still be encountered, including a relatively short half-life within the …

Drug targeting to the brain

AG De Boer, PJ Gaillard - Annu. Rev. Pharmacol. Toxicol., 2007 - annualreviews.org
The central nervous system (CNS) is a sanctuary site and is protected by various barriers.
These regulate brain homeostasis and the transport of endogenous and exogenous …

Caffeic acid loaded into engineered lipid nanoparticles for Alzheimer's disease therapy

S Andrade, MC Pereira, JA Loureiro - Colloids and Surfaces B …, 2023 - Elsevier
Alzheimer's disease (AD) is an incurable neurological illness and the leading cause of
dementia, characterized by amyloid β (Aβ) fibril deposits. Caffeic acid (CA) has …