Design, synthesis, and molecular docking studies of 5‐Bromoindole‐2‐carboxylic acid hydrazone derivatives: In vitro anticancer and VEGFR‐2 inhibitory effects
OM Hassan, AA Razzak Mahmood… - …, 2022 - Wiley Online Library
A new set of 5‐bromoindole‐2‐carboxylic acid hydrazone derivatives were synthesized and
studied as potential inhibitors of VEGFR‐2 tyrosine kinase (TK). Various physical (color …
studied as potential inhibitors of VEGFR‐2 tyrosine kinase (TK). Various physical (color …
Synthesis, characterization, anticancer activity and molecular docking of metal complexes bearing a new Schiff base ligand
((E)-((4-(((E)-4-Nitrobenzylidene) amino) phenyl) imino) methyl) naphthalen-1-ol, was
synthesised followed by metalation with Fe (III), Co (III), Cu (II), Zn (II) and Ni (II) metals. The …
synthesised followed by metalation with Fe (III), Co (III), Cu (II), Zn (II) and Ni (II) metals. The …
New combretastatin analogs as anticancer agents: Design, synthesis, microtubules polymerization inhibition, and molecular docking studies
SA Abdul Hussein, AA Razzak Mahmood… - Chemistry & …, 2023 - Wiley Online Library
Abstract A new series of 4‐(4‐methoxyphenyl)‐5‐(3, 4, 5‐trimethoxyphenyl)‐4H‐1, 2, 4‐
triazole‐3‐thiol derivatives were synthesized as analogs for the anticancer drug …
triazole‐3‐thiol derivatives were synthesized as analogs for the anticancer drug …
Novel 5-bromoindole-2-carboxylic acid derivatives as EGFR inhibitors: synthesis, docking study, and structure activity relationship
Background: The indole backbone is encountered in a class of N-heterocyclic compounds
with physiological and pharmacological effects such as anti-cancer, anti-diabetic, and anti …
with physiological and pharmacological effects such as anti-cancer, anti-diabetic, and anti …
Novel 1, 3, 4‐oxadiazole derivatives of naproxen targeting EGFR: Synthesis, molecular docking studies, and cytotoxic evaluation
HN Alsaad, BM AL‐Jasani… - Drug Development …, 2024 - Wiley Online Library
The close association between inflammation and cancer inspired the synthesis of a series of
1, 3, 4‐oxadiazole derivatives (compounds H4‐A‐F) of 6‐methoxynaphtalene. The chemical …
1, 3, 4‐oxadiazole derivatives (compounds H4‐A‐F) of 6‐methoxynaphtalene. The chemical …
[HTML][HTML] Synergistic Proliferation Effects of Xanthohumol and Niflumic Acid on Merkel and Glioblastoma Cancer Cells: Role of Cell Membrane Interactions
M Stompor-Gorący, A Włoch, P Sengupta… - International Journal of …, 2024 - mdpi.com
The objective of our research was to determine the effects of xanthohumol (XN), a flavonoid
isolated from hops (Humulus lupulus), and the anti-inflammatory drug niflumic acid (NA) …
isolated from hops (Humulus lupulus), and the anti-inflammatory drug niflumic acid (NA) …
Synthesis, In Silico Prediction, and In Vitro Evaluation of Anti-tumor Activities of Novel 4'-Hydroxybiphenyl-4-carboxylic Acid Derivatives as EGFR …
Introduction Allosteric inhibition of EGFR tyrosine kinase (TK) is currently among the most
attractive approaches for designing and developing anti-cancer drugs to avoid …
attractive approaches for designing and developing anti-cancer drugs to avoid …
New Niflumic Acid Derivatives as EGFR Inhibitors: Design, Synthesis, In-Silico Studies, and Anti-proliferative Assessment
Background: 1, 3, 4-oxadizole and pyrazole derivatives are very important scaffolds for
medicinal chemistry. A literature survey revealed that they possess a wide spectrum of …
medicinal chemistry. A literature survey revealed that they possess a wide spectrum of …
[HTML][HTML] In silico and in vitro evaluation of novel carbothioamide-based and heterocyclic derivatives of 4-(tert-butyl)-3-methoxybenzoic acid as EGFR tyrosine kinase …
Cancer is an elaborate sequence of disease grades that include uncontrolled cell growth
and division, invasion, and metastasis. Overexpression of the epidermal growth factor …
and division, invasion, and metastasis. Overexpression of the epidermal growth factor …
[HTML][HTML] Anti-Angiogenic and Anti-Proliferative Activity of 4-2-(5-bromo-1H-indol-2-carbonyl)-N-(4-methoxyphenyl) Hydrazine-1-carbothioamide: Ex-vivo and in vitro …
Angiogenesis, the formation of new blood vessels, stimulates tumor growth and spread by
delivering oxygen and nutrients, and is a key component of metastasis. This work aimed to …
delivering oxygen and nutrients, and is a key component of metastasis. This work aimed to …