19F NMR has emerged as a powerful tool in drug discovery, particularly in fragment-based
screens. The favorable magnetic resonance properties of the fluorine-19 nucleus, the …

Crystallography and cryo-electron microscopy have advanced atomic resolution
perspectives of inactive and active states of G protein-coupled receptors (GPCRs), alone …

Fluorine chemistry has taken a pivotal role in chemical reaction discovery, drug
development, and chemical biology. NMR spectroscopy, arguably the most important …

Fluorine NMR is a highly sensitive technique for delineating the conformational states of
biomolecules and has shown great utility in drug screening and in understanding protein …

Conspectus Inhibitor discovery for protein–protein interactions has proven difficult due to the
large protein surface areas and dynamic interfaces involved. This is particularly the case …

DFT calculations indicate that the 19F chemical shifts of aromatic rings containing single
fluorine substituents are sensitive to the electric fields and electric field gradients at the …

To elucidate the structures and dynamics of membrane proteins, highly advanced
biophysical methods have been developed that often require significant resources, both for …

Protein function is a consequence of a complex and dynamic equilibrium between
allosterically coupled functional states. However, it is often difficult to distinguish the …

Long-range interatomic distance restraints are critical for the determination of molecular
structures by NMR spectroscopy, both in solution and in the solid state. Fluorine is a …

Abstract 1 H and 19 F NMR methods based on chemical shift measurements of different
hydrogen bond donors used for quantifying hydrogen bond strength were analyzed and …