HIV and antiretroviral therapy-related fat alterations

JR Koethe, C Lagathu, JE Lake, P Domingo… - Nature reviews Disease …, 2020 - nature.com
Early in the HIV epidemic, lipodystrophy, characterized by subcutaneous fat loss
(lipoatrophy), with or without central fat accumulation (lipohypertrophy), was recognized as a …

Obesity and weight gain in persons with HIV

SS Bailin, CL Gabriel, CN Wanjalla… - Current HIV/AIDS Reports, 2020 - Springer
Abstract Purpose of Review The proportion of overweight and obese persons with HIV
(PWH) has increased since the introduction of antiretroviral therapy (ART). We aim to …

Specific biological features of adipose tissue, and their impact on HIV persistence

C Bourgeois, J Gorwood, A Barrail-Tran… - Frontiers in …, 2019 - frontiersin.org
Although white AT can contribute to anti-infectious immune responses, it can also be
targeted and perturbed by pathogens. The AT's immune involvement is primarily due to …

Beyond energy balance regulation: The underestimated role of adipose tissues in host defense against pathogens

J Barthelemy, G Bogard, I Wolowczuk - Frontiers in Immunology, 2023 - frontiersin.org
Although the adipose tissue (AT) is a central metabolic organ in the regulation of whole-
body energy homeostasis, it is also an important endocrine and immunological organ. As an …

Changes in subcutaneous white adipose tissue cellular composition and molecular programs underlie glucose intolerance in persons with HIV

SS Bailin, JA Kropski, RD Gangula, LT Hannah… - Frontiers in …, 2023 - frontiersin.org
Introduction Subcutaneous adipose tissue (SAT) is a critical regulator of systemic metabolic
homeostasis. Persons with HIV (PWH) have an increased risk of metabolic diseases and …

The hidden role of NLRP3 inflammasome in obesity‐related COVID‐19 exacerbations: lessons for drug repurposing

I Bertocchi, F Foglietta, D Collotta, C Eva… - British journal of …, 2020 - Wiley Online Library
COVID‐19, the illness caused by SARS‐CoV‐2, has a wide‐ranging clinical spectrum that,
in the worst‐case scenario, involves a rapid progression to severe acute respiratory …

The novel immune checkpoint GPR56 is expressed on tumor-infiltrating lymphocytes and selectively upregulated upon TCR signaling

V Bilemjian, MR Vlaming, J Álvarez Freile, G Huls… - Cancers, 2022 - mdpi.com
Simple Summary Despite the clinical efficacy of so-called immune checkpoint inhibitors
(ICIs) in various cancers, some cancer types, including epithelial ovarian cancer (EOC), do …

[HTML][HTML] CD4+ T cells expressing CX3CR1, GPR56, with variable CD57 are associated with cardiometabolic diseases in persons with HIV

CN Wanjalla, CL Gabriel, H Fuseini, SS Bailin… - Frontiers in …, 2023 - frontiersin.org
Persons with HIV (PWH) on long-term antiretroviral therapy (ART) have a higher incidence
and prevalence of cardiometabolic diseases attributed, in part, to persistent inflammation …

Inflammatory and immune mechanisms for atherosclerotic cardiovascular disease in HIV

L Hmiel, S Zhang, LM Obare, MAO Santana… - International journal of …, 2024 - mdpi.com
Atherosclerotic vascular disease disproportionately affects persons living with HIV (PLWH)
compared to those without. The reasons for the excess risk include dysregulated immune …

Clinical consequences of asymptomatic cytomegalovirus in treated human immunodeficency virus infection

SR Schnittman, PW Hunt - Current Opinion in HIV and AIDS, 2021 - journals.lww.com
Clinical consequences of asymptomatic cytomegalovirus in tre... : Current Opinion in HIV
and AIDS Clinical consequences of asymptomatic cytomegalovirus in treated human …