Orchestrating single-cell analysis with Bioconductor
Recent technological advancements have enabled the profiling of a large number of
genome-wide features in individual cells. However, single-cell data present unique …
genome-wide features in individual cells. However, single-cell data present unique …
[HTML][HTML] Data analysis guidelines for single-cell RNA-seq in biomedical studies and clinical applications
M Su, T Pan, QZ Chen, WW Zhou, Y Gong, G Xu… - Military Medical …, 2022 - Springer
The application of single-cell RNA sequencing (scRNA-seq) in biomedical research has
advanced our understanding of the pathogenesis of disease and provided valuable insights …
advanced our understanding of the pathogenesis of disease and provided valuable insights …
[HTML][HTML] Benchmarking UMI-based single-cell RNA-seq preprocessing workflows
Background Single-cell RNA-sequencing (scRNA-seq) technologies and associated
analysis methods have rapidly developed in recent years. This includes preprocessing …
analysis methods have rapidly developed in recent years. This includes preprocessing …
Accurate feature selection improves single-cell RNA-seq cell clustering
Cell clustering is one of the most important and commonly performed tasks in single-cell
RNA sequencing (scRNA-seq) data analysis. An important step in cell clustering is to select …
RNA sequencing (scRNA-seq) data analysis. An important step in cell clustering is to select …
Age-associated clonal B cells drive B cell lymphoma in mice
Although cancer is an age-related disease, how the processes of aging contribute to cancer
progression is not well understood. In this study, we uncovered how mouse B cell lymphoma …
progression is not well understood. In this study, we uncovered how mouse B cell lymphoma …
Progress and applications of single-cell sequencing techniques
A Yasen, A Aini, H Wang, W Li, C Zhang, B Ran… - Infection, Genetics and …, 2020 - Elsevier
Single-cell sequencing (SCS) is a next-generation sequencing method that is mainly used to
analyze differences in genetic and protein information between cells, to obtain genetic …
analyze differences in genetic and protein information between cells, to obtain genetic …
Sex differences in behavioral and brainstem transcriptomic neuroadaptations following neonatal opioid exposure in outbred mice
The opioid epidemic led to an increase in the number of neonatal opioid withdrawal
syndrome (NOWS) cases in infants born to opioid-dependent mothers. Hallmark features of …
syndrome (NOWS) cases in infants born to opioid-dependent mothers. Hallmark features of …
GABA regulates the proliferation and apoptosis of head and neck squamous cell carcinoma cells by promoting the expression of CCND2 and BCL2L1
K Luo, X Zhao, Y Shan, X Wang, Y Xu, M Chen… - Life Sciences, 2023 - Elsevier
Gamma-aminobutyric acid (GABA) is a multifunctional molecule that is widely present in the
nervous system and nonneuronal tissues. It plays pivotal roles in neurotransmission …
nervous system and nonneuronal tissues. It plays pivotal roles in neurotransmission …
HumanIslets: An integrated platform for human islet data access and analysis
Comprehensive molecular and cellular phenotyping of human islets can enable deep
mechanistic insights for diabetes research. We established the Human Islet Data Analysis …
mechanistic insights for diabetes research. We established the Human Islet Data Analysis …
Single-cell RNA-seq reveals invasive trajectory and determines cancer stem cell-related prognostic genes in pancreatic cancer
X Ren, C Zhou, Y Lu, F Ma, Y Fan, C Wang - Bioengineered, 2021 - Taylor & Francis
Pancreatic duct adenocarcinoma (PDAC) is an aggressive and lethal malignancy.
Pancreatic cancer stem cells (PCSCs) are assumed to contribute to the initiation and …
Pancreatic cancer stem cells (PCSCs) are assumed to contribute to the initiation and …