Being deeply connected to signalling, cell dynamics, growth, regulation, and defence,
endocytic processes are linked to almost all aspects of cell life and disease. In this review …

Nanoparticles (NP) are attractive options for the therapeutic delivery of active
pharmaceutical drugs, proteins and nucleic acids into cells, tissues and organs. Research …

Autophagy is primarily considered a non‐selective degradation process induced by
starvation. Nutrient‐independent basal autophagy, in contrast, imposes intracellular QC by …

Foreign particles and apoptotic bodies are eliminated from the body by phagocytic
leucocytes. The initial stage of the elimination process is the internalization of the particles …

Following phagocytosis, the nascent phagosome undergoes maturation to become a
phagolysosome with an acidic, hydrolytic, and often oxidative lumen that can efficiently kill …

Since the discovery of insulin roughly 80 yr ago, much has been learned about how target
cells receive, interpret, and respond to this peptide hormone. For example, we now know …

Phagosomes are fascinating subcellular structures. After all, there are only a few
compartments that are born before our very eyes and whose development we can follow in a …

Pathogenic mycobacteria such as Mycobacterium tuberculosis and Mycobacterium avium
facilitate disease by surviving intracellularly within a potentially hostile environment: the …

The ability of macrophages to clear pathogens and elicit a sustained immune response is
regulated by various cytokines, including interferon-γ (IFN-γ). To investigate the molecular …

Inflammasomes are multiprotein complexes that include members of the NLR (nucleotide-
binding domain leucine-rich repeat containing) family and caspase-1. Once bacterial …