Methods for three-dimensional all-optical manipulation of neural circuits

E Ronzitti, V Emiliani… - Frontiers in Cellular …, 2018 - frontiersin.org
Optical means for modulating and monitoring neuronal activity, have provided substantial
insights to neurophysiology and toward our understanding of how the brain works …

The development and application of opto-chemical tools in the zebrafish

Z Feng, B Ducos, P Scerbo, I Aujard, L Jullien… - Molecules, 2022 - mdpi.com
The zebrafish is one of the most widely adopted animal models in both basic and
translational research. This popularity of the zebrafish results from several advantages such …

Highly efficient Ca 2+ chelation activated by visible light

NM Egodawaththa, O Rajhel, J Ma, C Guruge… - Organic & …, 2024 - pubs.rsc.org
Calcium ion (Ca2+) control is an essential tool in neuronal research. Herein, we report three
thiocoumarin-based, visible light-activated Ca2+ chelators with quantum yields of 0.39, 0.52 …

Blue and green light responsive caged glutamate

J Ma, NM Egodawaththa, C Guruge… - … of Photochemistry and …, 2024 - Elsevier
Glutamate (Glu) is an excitatory neurotransmitter that plays a critical role in memory. Brain
mapping activities of such pathways relied heavily on the ability to release Glu with …

Caged proline in photoinitiated organocatalysis

C Guruge, SY Rfaish, C Byrd, S Yang… - The Journal of …, 2019 - ACS Publications
Organocatalysis is an emerging field, in which small metal-free organic structures catalyze a
diversity of reactions with a remarkable stereoselectivity. The ability to selectively switch on …

Competition between cyclization and unusual Norrish type I and type II nitro-acyl migration pathways in the photouncaging of 1-acyl-7-nitroindoline revealed by …

P Morgante, C Guruge, YP Ouedraogo, N Nesnas… - Scientific Reports, 2021 - nature.com
The 7-nitroindolinyl family of caging chromophores has received much attention in the past
two decades. However, its uncaging mechanism is still not clearly understood. In this study …

Highly Efficient Visible Light-Induced Ca2+ Chelation

NM Egodawaththa, O Rajhel, J Ma, C Guruge… - 2024 - chemrxiv.org
Calcium ion (Ca2+) control is an essential tool in neuronal research. Herein, we report three
thiocoumarin-based, visi-ble light-activated Ca2+ chelators with high quantum yields of 0.39 …

Synthesis of kainic acid derivatives and their application as kainate receptors probes

Z Tian - 2019 - open.library.ubc.ca
Kainate receptors play important roles in the central nervous system. However, investigating
their role in physiology is hampered by the current lack of tools to study them in dynamic …

Control of Irradiation Wavelength and Quantum Yield of Photocleavable Cages

J Ma - 2022 - repository.fit.edu
An important component of biological research is the precise regulation of biomolecules in
their physiological environment. Recent advances in neuroscience, have made it possible to …

Unusual Norrish Type I and Type II Nitro-Acyl Migration Transition State in the Photo-Uncaging of 1-Acyl-7-Nitroindolines Revealed by Computations

P Morgante, C Guruge, YP Ouedraogo, N Nesnas… - 2020 - chemrxiv.org
The 7-nitroindolinyl family of caging chromophores has received a lot of attention in the past
two decades. However, it is not clear if they undergo cyclization or migration upon photo …