[HTML][HTML] Odorant receptors in cancer

C Chung, HJ Cho, CE Lee, JH Koo - BMB reports, 2022 - ncbi.nlm.nih.gov
Odorant receptors (ORs), the largest subfamily of G protein-coupled receptors, detect
odorants in the nose. In addition, ORs were recently shown to be expressed in many …

The macrophage odorant receptor Olfr78 mediates the lactate-induced M2 phenotype of tumor-associated macrophages

SMP Vadevoo, GR Gunassekaran… - Proceedings of the …, 2021 - National Acad Sciences
Expression and function of odorant receptors (ORs), which account for more than 50% of G
protein–coupled receptors, are being increasingly reported in nonolfactory sites. However …

The structure and function of olfactory receptors

C Wu, M Xu, J Dong, W Cui, S Yuan - Trends in Pharmacological Sciences, 2024 - cell.com
Olfactory receptors (ORs) form the most important chemosensory receptor family responsible
for our sense of smell in the nasal olfactory epithelium. This receptor family belongs to the …

A MYCN-driven de-differentiation profile identifies a subgroup of aggressive retinoblastoma

T Ryl, E Afanasyeva, T Hartmann… - Communications …, 2024 - nature.com
Retinoblastoma are childhood eye tumors arising from retinal precursor cells. Two distinct
retinoblastoma subtypes with different clinical behavior have been described based on gene …

Odorant receptors as potential drug targets

RG Naressi, D Schechtman, B Malnic - Trends in Pharmacological …, 2023 - cell.com
Odorant receptors (ORs) belong to a large family of G protein-coupled receptors (GPCRs)
that are highly expressed by olfactory sensory neurons of the nose. Accumulating evidence …

OdoriFy: a conglomerate of artificial intelligence–driven prediction engines for olfactory decoding

R Gupta, A Mittal, V Agrawal, S Gupta, K Gupta… - Journal of Biological …, 2021 - ASBMB
The molecular mechanisms of olfaction, or the sense of smell, are relatively underexplored
compared with other sensory systems, primarily because of its underlying molecular …

The Expression of Trace Amine-Associated Receptors (TAARs) in Breast Cancer Is Coincident with the Expression of Neuroactive Ligand–Receptor Systems and …

AN Vaganova, DD Maslennikova, VV Konstantinova… - Biomolecules, 2023 - mdpi.com
Currently, the contribution of trace amine-associated receptors (TAARs) to breast cancer
(BC) is recognized, but their associations with various pathological characteristics are not …

Rearrangement-mediated cis-regulatory alterations in advanced patient tumors reveal interactions with therapy

Y Zhang, F Chen, E Pleasance, L Williamson… - Cell reports, 2021 - cell.com
The global impact of somatic structural variants (SVs) on gene regulation in advanced
tumors with complex treatment histories has been mostly uncharacterized. Here, using …

[HTML][HTML] Odorant G protein-coupled receptors as potential therapeutic targets for adult diffuse gliomas: a systematic analysis and review

HJ Cho, JH Koo - BMB reports, 2021 - ncbi.nlm.nih.gov
Odorant receptors (ORs) account for about 60% of all human G protein-coupled receptors
(GPCRs). OR expression outside of the nose has functions distinct from odor perception …

[HTML][HTML] Comprehensive Transcriptomic Analysis Reveals Cell-Type-Specific Roles of Human Odorant Receptors in Glioblastoma and the Tumor Microenvironment

HJ Cho, DJ Yeo, HW Yang, JH Koo - International Journal of Molecular …, 2024 - mdpi.com
Odorant receptors (ORs), which constitute approximately 50% of all human G protein-
coupled receptors, are increasingly recognized for their diverse roles beyond odor …