CGRP physiology, pharmacology, and therapeutic targets: migraine and beyond
Calcitonin gene-related peptide (CGRP) is a neuropeptide with diverse physiological
functions. Its two isoforms (α and β) are widely expressed throughout the body in sensory …
functions. Its two isoforms (α and β) are widely expressed throughout the body in sensory …
[HTML][HTML] The regulation of oncogenic Ras/ERK signalling by dual-specificity mitogen activated protein kinase phosphatases (MKPs)
Dual-specificity MAP kinase (MAPK) phosphatases (MKPs or DUSPs) are well-established
negative regulators of MAPK signalling in mammalian cells and tissues. By virtue of their …
negative regulators of MAPK signalling in mammalian cells and tissues. By virtue of their …
DUSPs, to MAP kinases and beyond
CY Huang, TH Tan - Cell & bioscience, 2012 - Springer
Phosphatases are important regulators of intracellular signaling events, and their functions
have been implicated in many biological processes. Dual-specificity phosphatases …
have been implicated in many biological processes. Dual-specificity phosphatases …
[HTML][HTML] An overview of mammalian p38 mitogen-activated protein kinases, central regulators of cell stress and receptor signaling
The p38 family is a highly evolutionarily conserved group of mitogen-activated protein
kinases (MAPKs) that is involved in and helps co-ordinate cellular responses to nearly all …
kinases (MAPKs) that is involved in and helps co-ordinate cellular responses to nearly all …
[HTML][HTML] Dual-specificity MAP kinase phosphatases in health and disease
It is well established that a family of dual-specificity MAP kinase phosphatases (MKPs) play
key roles in the regulated dephosphorylation and inactivation of MAP kinase isoforms in …
key roles in the regulated dephosphorylation and inactivation of MAP kinase isoforms in …
The extended human PTP ome: A growing tyrosine phosphatase family
A Alonso, R Pulido - The FEBS journal, 2016 - Wiley Online Library
Tyr phosphatases are, by definition, enzymes that dephosphorylate phospho‐Tyr (pT yr)
from proteins. This activity is found in several structurally diverse protein families, including …
from proteins. This activity is found in several structurally diverse protein families, including …
Protein tyrosine phosphatases in health and disease
WJAJ Hendriks, A Elson, S Harroch, R Pulido… - The FEBS …, 2013 - Wiley Online Library
Protein tyrosine phosphatases (PTP s) represent a super‐family of enzymes that play
essential roles in normal development and physiology. In this review, we will discuss the …
essential roles in normal development and physiology. In this review, we will discuss the …
[HTML][HTML] Human branching cholangiocyte organoids recapitulate functional bile duct formation
Human cholangiocyte organoids show great promise for regenerative therapies and in vitro
modeling of bile duct development and diseases. However, the cystic organoids lack the …
modeling of bile duct development and diseases. However, the cystic organoids lack the …
Atypical p38 signaling, activation, and implications for disease
JC Burton, W Antoniades, J Okalova, MM Roos… - International Journal of …, 2021 - mdpi.com
The mitogen-activated protein kinase (MAPK) p38 is an essential family of kinases,
regulating responses to environmental stress and inflammation. There is an ever-increasing …
regulating responses to environmental stress and inflammation. There is an ever-increasing …
Tumor suppressive protein phosphatases in human cancer: Emerging targets for therapeutic intervention and tumor stratification
B Meeusen, V Janssens - The international journal of biochemistry & cell …, 2018 - Elsevier
Aberrant protein phosphorylation is one of the hallmarks of cancer cells, and in many cases
a prerequisite to sustain tumor development and progression. Like protein kinases, protein …
a prerequisite to sustain tumor development and progression. Like protein kinases, protein …