Cellular, molecular, and clinical mechanisms of action of deep brain stimulation—a systematic review on established indications and outlook on future developments

M Jakobs, A Fomenko, AM Lozano… - EMBO molecular …, 2019 - embopress.org
Deep brain stimulation (DBS) has been successfully used to treat movement disorders, such
as Parkinson's disease, for more than 25 years and heralded the advent of electrical …

Challenges in PD patient management after DBS: a pragmatic review

M Rossi, V Bruno, J Arena… - Movement Disorders …, 2018 - Wiley Online Library
Background Deep brain stimulation (DBS) of the subthalamic nucleus (STN) or internal
globus pallidus (GPi) represents an effective and universally applied therapy for Parkinson's …

Effects of subthalamic deep brain stimulation on non‐motor symptoms of Parkinson's disease: A meta‐analysis

Z Eghlidos, Z Rahimian, G Vadiee… - Acta Neurologica …, 2022 - Wiley Online Library
Deep brain stimulation (DBS) is a well‐defined treatment for motor symptoms in advanced
PD. Although several studies have investigated the DBS effect on non‐motor symptoms …

Effect of deep brain stimulation on postoperative body mass index: A systematic review and meta-analysis

AR Bahadori, P Javadnia, S Dahaghin… - Neurosurgical …, 2024 - Springer
Abstract Background Deep Brain Stimulation (DBS) is FDA-approved for several movement
disorders; such as Parkinson's disease, dystonia, and neuropsychiatric disorders. There are …

Clinical impact of deep brain stimulation on the autonomic system in patients with Parkinson's disease

G Bellini, LA Best, U Brechany, R Mills… - Movement Disorders …, 2020 - Wiley Online Library
Background The role of deep brain stimulation (DBS) in the management of motor symptoms
in patients with Parkinson's disease is well defined. However, it is becoming increasingly …

Weight in Parkinson's disease: phenotypical significance

JC Sharma, A Lewis - International review of neurobiology, 2017 - Elsevier
Body weight in Parkinson's disease (PD) is a significant nonmotor feature. Weight
homeostasis is a complex physiological process and gets deranged in PD patients leading …

Apathy following Bilateral Deep Brain Stimulation of Subthalamic Nucleus and Globus Pallidus Internus in Parkinson's Disease: A Meta‐Analysis

S Zhang, S Zi, S Xiong, H Peng, K Hu… - Parkinson's …, 2022 - Wiley Online Library
Parkinson's disease (PD) is a progressive neurodegenerative disorder typically manifested
by its motor symptoms. In addition, PD patients also suffer from many nonmotor symptoms …

Sweets for my sweet: modulation of the limbic system drives salience for sweet foods after deep brain stimulation in Parkinson's disease

J Steinhardt, H Hanssen, M Heldmann… - Journal of Neurology …, 2022 - jnnp.bmj.com
Background An increase in body weight is observed in the majority of patients with
Parkinson's disease (PD) who undergo deep brain stimulation (DBS) of the subthalamic …

Imaging the nonmotor symptoms in Parkinson's disease

T Yousaf, H Wilson, M Politis - International review of neurobiology, 2017 - Elsevier
Parkinson's disease is acknowledged to be a multisystem syndrome, manifesting as a result
of multineuropeptide dysfunction, including dopaminergic, cholinergic, serotonergic, and …

Deep brain stimulation—possible treatment strategy for pathologically altered body weight?

P Prinz, A Stengel - Brain Sciences, 2018 - mdpi.com
The treatment of obesity and eating disorders such as binge-eating disorder or anorexia
nervosa is challenging. Besides lifestyle changes and pharmacological options, bariatric …