There exists a phenomenon in aging research whereby early life stress can have positive
impacts on longevity. The mechanisms underlying these observations suggest a robust, long …

As a central hub of cellular metabolism and signaling, the mitochondrion is a crucial
organelle whose dysfunction can cause disease and whose activity is intimately connected …

We have previously proposed that selective inheritance, the limited transmission of
damaging mtDNA mutations from mother to offspring, is based on replication competition in …

Mitochondrial dynamics are known to have an important role in so-called age-related
diseases, including cancer. Mitochondria is an organelle involved in many key cellular …

Peroxisomes and mitochondria are the main intracellular sources for reactive oxygen
species. At the same time, both organelles are critical for the maintenance of a healthy redox …

Decline of mitochondrial function is a hallmark of cellular aging. To counteract this process,
some cells inherit mitochondria asymmetrically to rejuvenate daughter cells. The molecular …

In multicellular organisms, neurons integrate a diverse array of external cues to affect
downstream changes in organismal health. Specifically, activation of the endoplasmic …

As centers for energy production and essential biosynthetic activities, mitochondria are vital
for cell growth and proliferation. Accumulating evidence suggests an integrated regulation of …

Partitioning of cell organelles and cytoplasmic components determines the fate of daughter
cells upon asymmetric division. We studied the role of mitochondria in this process using …

Mitochondrial genetics started decades ago with the discovery of yeast mutants that ignored
the Mendelian rules of inheritance. Today, the many known DNA sequences of this second …