Circadian Mechanisms in Medicine Molecular insights into diurnal variations in human
physiology and behavior are extending our understanding of a wide range of disease …

BACKGROUND Life-forms ranging from bacteria to humans are programmed by circadian
clocks—mechanisms that impose an~ 24-hour rhythmicity on biology in harmony with …

Humans, like all mammals, partition their daily behaviour into activity (wakefulness) and rest
(sleep) phases that differ largely in their metabolic requirements. The circadian clock …

The circadian clock and feeding rhythms are both important regulators of rhythmic gene
expression in the liver. To further dissect the respective contributions of feeding and the …

The epidemic of Type 2 diabetes mellitus necessitates development of novel therapeutic
and preventative strategies to attenuate expansion of this debilitating disease. Evidence …

Many molecular, physiological and behavioural processes display distinct 24-hour rhythms
that are directed by the circadian system. The master clock, located in the suprachiasmatic …

The circadian system is composed of coupled endogenous oscillators that allow living
beings, including humans, to anticipate and adapt to daily changes in their environment. In …

The finding that animals with circadian gene mutations exhibit diet-induced obesity and
metabolic syndrome with hypoinsulinemia revealed a distinct role for the clock in the brain …

The circadian clock provides cue-independent anticipatory signals for diurnal rhythms of
baseline glucose levels and glucose tolerance. The central circadian clock is located in the …

The circadian clock exerts an important role in systemic homeostasis as it acts a keeper of
time for the organism. The synchrony between the daily challenges imposed by the …