Central nervous system (CNS) maintains a high level of metabolism, which leads to the
generation of large amounts of free radicals, and it is also one of the most vulnerable organs …

Mitochondria fulfill numerous cellular functions including ATP production, Ca2+ buffering,
neurotransmitter synthesis and degradation, ROS production and sequestration, apoptosis …

Neuronal cytotoxic edema is the morphological correlate of the near-complete neuronal
battery breakdown called spreading depolarization, or conversely, spreading depolarization …

The multifunctional protein, voltage-dependent anion channel 1 (VDAC1), is located on the
mitochondrial outer membrane. It is a pivotal protein that maintains mitochondrial function to …

Parkinson's disease (PD) is a progressive neurodegenerative disorder characterized by the
loss of dopaminergic neurons in the substantia nigra pars compacta, leading to motor …

Dysregulation of mitochondrial Ca2+ homeostasis has been linked to neurodegenerative
diseases. Mitochondrial Ca2+ uptake is mediated via the calcium uniporter complex that is …

With a rise in the incidence of autoimmune diseases (AiD), health care providers continue to
seek out more efficacious treatment approaches for the AiD patient population. Classic …

Thus far, the potential short-and long-term detrimental effects of a variety of environmental
chemicals designated as endocrine-active compounds (EACs) have been found to interfere …

Background Within 2 min of severe ischemia, spreading depolarization (SD) propagates like
a wave through compromised gray matter of the higher brain. More SDs arise over hours in …

Respiratory diseases are one of the most common pediatric diseases in clinical practice.
Their pathogenesis, diagnosis, and treatment are thus worthy of further investigation. The …