m6A modification: recent advances, anticancer targeted drug discovery and beyond
LJ Deng, WQ Deng, SR Fan, MF Chen, M Qi, WY Lyu… - Molecular cancer, 2022 - Springer
Abstract Abnormal N6-methyladenosine (m6A) modification is closely associated with the
occurrence, development, progression and prognosis of cancer, and aberrant m6A …
occurrence, development, progression and prognosis of cancer, and aberrant m6A …
The role of m6A, m5C and Ψ RNA modifications in cancer: Novel therapeutic opportunities
RNA modifications have recently emerged as critical posttranscriptional regulators of gene
expression programmes. Significant advances have been made in understanding the …
expression programmes. Significant advances have been made in understanding the …
Histone lactylation drives oncogenesis by facilitating m6A reader protein YTHDF2 expression in ocular melanoma
Background Histone lactylation, a metabolic stress-related histone modification, plays an
important role in the regulation of gene expression during M1 macrophage polarization …
important role in the regulation of gene expression during M1 macrophage polarization …
The potential role of RNA N6-methyladenosine in Cancer progression
T Wang, S Kong, M Tao, S Ju - Molecular cancer, 2020 - Springer
Abstract N6-methyladenosine (m6A) is considered the most common, abundant, and
conserved internal transcript modification, especially in eukaryotic messenger RNA (mRNA) …
conserved internal transcript modification, especially in eukaryotic messenger RNA (mRNA) …
Roles of METTL3 in cancer: mechanisms and therapeutic targeting
C Zeng, W Huang, Y Li, H Weng - Journal of hematology & oncology, 2020 - Springer
Abstract N 6-methyladenosine (m 6 A) is the most abundant mRNA modification and is
catalyzed by the methyltransferase complex, in which methyltransferase-like 3 (METTL3) is …
catalyzed by the methyltransferase complex, in which methyltransferase-like 3 (METTL3) is …
HIF-1α-induced expression of m6A reader YTHDF1 drives hypoxia-induced autophagy and malignancy of hepatocellular carcinoma by promoting ATG2A and ATG14 …
Q Li, Y Ni, L Zhang, R Jiang, J Xu, H Yang… - Signal transduction and …, 2021 - nature.com
Abstract N6-methyladenosine (m6A), and its reader protein YTHDF1, play a pivotal role in
human tumorigenesis by affecting nearly every stage of RNA metabolism. Autophagy …
human tumorigenesis by affecting nearly every stage of RNA metabolism. Autophagy …
N6-methyladenosine METTL3 promotes cervical cancer tumorigenesis and Warburg effect through YTHDF1/HK2 modification
Q Wang, X Guo, L Li, Z Gao, X Su, M Ji, J Liu - Cell death & disease, 2020 - nature.com
Abstract N6-methyladenosine (m6A) serves as the most common and conserved internal
transcriptional modification. However, the roles of m6A on cervical cancer (CC) …
transcriptional modification. However, the roles of m6A on cervical cancer (CC) …
METTL3 promotes lung adenocarcinoma tumor growth and inhibits ferroptosis by stabilizing SLC7A11 m6A modification
Y Xu, D Lv, C Yan, H Su, X Zhang, Y Shi, K Ying - Cancer cell international, 2022 - Springer
Abstract Background N6-methyladenosine (m6A) has emerged as a significant regulator of
the progress of various cancers. However, its role in lung adenocarcinoma (LUAD) remains …
the progress of various cancers. However, its role in lung adenocarcinoma (LUAD) remains …
The role of N6-methyladenosine (m6A) modification in the regulation of circRNAs
L Zhang, C Hou, C Chen, Y Guo, W Yuan, D Yin, J Liu… - Molecular cancer, 2020 - Springer
Abstract N 6-methyladenosine (m 6 A), the most abundant modification in eukaryotic cells,
regulates RNA transcription, processing, splicing, degradation, and translation. Circular …
regulates RNA transcription, processing, splicing, degradation, and translation. Circular …
Mechanism of RNA modification N6-methyladenosine in human cancer
Z Zhou, J Lv, H Yu, J Han, X Yang, D Feng, Q Wu… - Molecular cancer, 2020 - Springer
Since the breakthrough discoveries of DNA and histone modifications, the field of RNA
modifications has gained increasing interest in the scientific community. The discovery of N6 …
modifications has gained increasing interest in the scientific community. The discovery of N6 …