HU-AB simulacrum: Fusion of HU-B and HU-A into HU-BA, a functional analog of the Escherichia coli HU-AB heterodimer

K Arora, B Thakur, A Gupta, P Guptasarma - Biochemical and Biophysical …, 2021 - Elsevier
In enteric bacteria such as Escherichia coli, there are two homologs of the DNA-binding
nucleoid associated protein (NAP) known as HU. The two homologs are known as HU-A …

N-terminal extensions appear to frustrate HU heterodimer formation by strengthening intersubunit contacts and blocking the formation of a heterotetrameric …

K Arora, B Thakur, A Mrigwani, P Guptasarma - Biochemistry, 2021 - ACS Publications
HU is a bacterial nucleoid-associated protein. Two homologues, known as HU-A, and HU-B,
are found in Escherichia coli within which the early, late, and stationary phases of growth are …

Newly-discovered behaviour in the bacterial histone-like protein, HU

A Gupta, B Thakur, K Arora… - Indian Journal of …, 2023 - or.niscpr.res.in
This paper summarizes the contents of a talk delivered at the MS University of Baroda
(Vadodara, Gujarat) on 3 rd March, 2023, at a conference held to celebrate proteins in …

N-terminal extensions strengthen hydrophobic inter-subunit interactions between HU's C-terminal domains to frustrate heterodimer formation

K Arora, B Thakur, A Mrigwani, P Guptasarma - bioRxiv, 2021 - biorxiv.org
HU is a nucleoid-associated protein (NAP) that helps bacterial chromosomal DNA to remain
compact. Escherichia coli contains two homologs of HU that are~ 70% identical: HU-A and …