Rho GTPases comprise a family of molecular switches that control signal transduction
pathways in eukaryotic cells. A conformational change induced upon binding GTP promotes …

The actin cytoskeleton mediates a variety of essential biological functions in all eukaryotic
cells. In addition to providing a structural framework around which cell shape and polarity …

The Rho GTPases form a subgroup of the Ras superfamily of 20-to 30-kD GTP-binding
proteins that have been shown to regulate a wide spectrum of cellular functions. These …

The signaling pathways mediated by Rho family GTPases have been implicated in many
aspects of cell biology. The specificity of the pathways is achieved in part by the selective …

▪ Abstract The 3-phosphorylated inositol lipids fulfill roles as second messengers by
interacting with the lipid binding domains of a variety of cellular proteins. Such interactions …

Rho GTPases control many aspects of cell behavior through the regulation of multiple signal
transduction pathways (Van Aelst and D'Souza-Schorey 1997; Hall 1998). Rho, Rac, and …

▪ Abstract Members of the Rho family of small Ras-like GTPases—including RhoA,-B, and-C,
Rac1 and-2, and Cdc42—exhibit guanine nucleotide-binding activity and function as …

The PAK family of kinases are regulated through interaction with the small GTPases Cdc42
and Rac1, but little is known of the signaling components immediately upstream or …

Adhesion to ECM is required for many cell functions including cytoskeletal organization,
migration, and proliferation. We observed that when cells first adhere to extracellular matrix …

Cdc42p is an essential GTPase that belongs to the Rho/Rac subfamily of Ras-like GTPases.
These proteins act as molecular switches by responding to exogenous and/or endogenous …