[HTML][HTML] Nanostructured lipid carriers (NLCs) as drug delivery platform: Advances in formulation and delivery strategies

M Elmowafy, MM Al-Sanea - Saudi Pharmaceutical Journal, 2021 - Elsevier
NLCs have provoked the incessant impulsion for the development of safe and valuable drug
delivery systems owing to their exceptional physicochemical and then biocompatible …

Surface modification of lipid-based nanoparticles

Y Xu, T Fourniols, Y Labrak, V Préat, A Beloqui… - ACS …, 2022 - ACS Publications
There is a growing interest in the development of lipid-based nanocarriers for multiple
purposes, including the recent increase of these nanocarriers as vaccine components …

Novel drug delivery systems for the management of dry eye

N Nagai, H Otake - Advanced drug delivery reviews, 2022 - Elsevier
Dry eye disease (DED) is a frequently observed eye complaint, which has recently attracted
considerable research interest. Conventional therapy for DED involves the use of artificial …

Nanostructured lipid carriers: Promising drug delivery systems for future clinics

A Beloqui, MÁ Solinís, A Rodríguez-Gascón… - … , biology and medicine, 2016 - Elsevier
During the past decade, the number of studies describing nanostructured lipid carriers
(NLCs)-based formulations has been dramatically increased. The raise in NLC exploitation …

Nanoparticles for drug delivery to the anterior segment of the eye

DR Janagam, L Wu, TL Lowe - Advanced drug delivery reviews, 2017 - Elsevier
Commercially available ocular drug delivery systems are effective but less efficacious to
manage diseases/disorders of the anterior segment of the eye. Recent advances in …

[HTML][HTML] Strategies to prolong the residence time of drug delivery systems on ocular surface

B Grassiri, Y Zambito, A Bernkop-Schnürch - Advances in colloid and …, 2021 - Elsevier
Ocular diseases may be treated via different routes of administration, such as topical,
intracameral, intravitreal, oral and parenteral. Among them the topical route is most accepted …

Preclinical safety of solid lipid nanoparticles and nanostructured lipid carriers: Current evidence from in vitro and in vivo evaluation

S Doktorovova, AB Kovačević, ML Garcia… - European Journal of …, 2016 - Elsevier
Solid lipid nanoparticles (SLN) and nanostructured lipid carriers (NLC) were designed as
exceptionally safe colloidal carriers for the delivery of poorly soluble drugs. SLN/NLC have …

Mucoadhesive nanostructured lipid carriers as a cannabidiol nasal delivery system for the treatment of neuropathic pain

AP Matarazzo, LMS Elisei, FC Carvalho… - European Journal of …, 2021 - Elsevier
The therapeutic potential of cannabidiol (CBD) has been explored to treat several
pathologies, including those in which pain is prevalent. However, the oral bioavailability of …

Recent advances in topical ophthalmic drug delivery with lipid-based nanocarriers

L Gan, J Wang, M Jiang, H Bartlett, D Ouyang… - Drug discovery today, 2013 - Elsevier
Ocular barriers and the poor water solubility of drug candidates present a number of
problems for the development of ocular drug delivery systems. Recently, the emergence of …

Untangling mucosal drug delivery: engineering, designing, and testing nanoparticles to overcome the mucus barrier

J Watchorn, AJ Clasky, G Prakash… - ACS Biomaterials …, 2022 - ACS Publications
Mucus is a complex viscoelastic gel and acts as a barrier covering much of the soft tissue in
the human body. High vascularization and accessibility have motivated drug delivery to …