Molecular dynamics simulations of membrane proteins are making rapid progress, because
of new high-resolution structures, advances in computer hardware and atomistic simulation …

To understand the molecular mechanism of ion permeation in pentameric ligand‐gated ion
channels (pLGIC), we solved the structure of an open form of GLIC, a prokaryotic pLGIC, at …

The Cys-loop receptor superfamily of ligand-gated ion channels has a prominent role in
neuronal signalling. These receptors are pentamers, each subunit containing ten β-strands …

Protein kinase A (PKA) is a ubiquitous phosphoryl transferase that mediates hundreds of cell
signaling events. During turnover, its catalytic subunit (PKA-C) interconverts between three …

Magnesium translocation across cell membranes is essential for numerous physiological
processes. Three recently reported crystal structures of the CorA magnesium transport …

Acetylcholine receptor channel gating is a propagated conformational cascade that links
changes in structure and function at the transmitter binding sites in the extracellular domain …

Positive allosteric modulators (PAMs) of nicotinic acetylcholine receptors (nAChRs) have
attracted considerable interest as a novel area of therapeutic drug discovery. Two types of …

Determining the structure of the ligand-binding domain of the nicotinic acetylcholine receptor
(nAChR) has been a long standing goal in the design of selective drugs useful in implicated …

Escherichia coli NikR is a homotetrameric Ni2+-and DNA-binding protein that functions as a
transcriptional repressor of the NikABCDE nickel permease. The protein is composed of two …

RDL receptors are GABA-activated inhibitory Cys-loop receptors found throughout the insect
CNS. They are a key target for insecticides. Here, we characterize the GABA binding site in …