Tumor‐derived cell lines play an important role in the investigation of tumor biology and
genetics. Across a wide array of studies, they have been tools of choice for the discovery of …

Metastatic disease is the principal cause of prostate-cancer-related mortality. Our ability to
accurately recapitulate the spread of prostate cancer to bone—the most common site of …

New incidence of prostate cancer is a major public health issue in the Western world, and
has been rising in other areas of the globe in recent years. In an effort to understanding the …

The p53 tumour suppressor has an important role in cancer cells. Here we show that p53
regulates expression of major histocompatibility complex I on the cell surface. We show that …

Prostate cancer is a common malignant tumor, which can spread to multiple organs in the
body. Metastatic disease is the dominant reason of death for patients with prostate cancer …

Abstract p28 is an anionic cell-penetrating peptide of 28 amino acids that activates wild-type
and mutated p53, leading subsequently to selective inhibition of CDK2 and cyclin A …

Background Tissue exudates contain low levels of serum complement proteins, and their
regulatory effects on prostate cancer progression are largely unknown. We examined …

Because p53 inactivation may limit the effectiveness of radiation therapy for localized
prostate cancer, it is important to understand how this gene regulates clonogenic survival …

CD24 is overexpressed in nearly 70% human cancers, whereas TP53 is the most frequently
mutated tumour-suppressor gene that functions in a context-dependent manner. Here we …

Purpose: To evaluate the potential of hyperpolarized [1-13C]-pyruvate magnetic resonance
spectroscopic imaging (MRSI) of prostate cancer as a predictive biomarker for targeting the …