The endocannabinoid system as a putative target for the development of novel drugs for the treatment of psychiatric illnesses
Cannabis is well established to impact affective states, emotion and perceptual processing,
primarily through its interactions with the endocannabinoid system. While cannabis use is …
primarily through its interactions with the endocannabinoid system. While cannabis use is …
Cannabinoid metabolites as inhibitors of major hepatic CYP450 enzymes, with implications for cannabis-drug interactions
S Nasrin, CJW Watson, YX Perez-Paramo… - Drug Metabolism and …, 2021 - ASPET
The legalization of cannabis in many parts of the United States and other countries has led
to a need for a more comprehensive understanding of cannabis constituents and their …
to a need for a more comprehensive understanding of cannabis constituents and their …
Inhibition of UDP-glucuronosyltransferase enzymes by major cannabinoids and their metabolites
The UDP-glucuronosyltransferase (UGT) family of enzymes play a central role in the
metabolism and detoxification of a wide range of endogenous and exogenous compounds …
metabolism and detoxification of a wide range of endogenous and exogenous compounds …
Differential interactions of selected phytocannabinoids with human CYP2D6 polymorphisms
Cytochrome P450 2D6 (CYP2D6) is primarily expressed in the liver and in the central
nervous system. It is known to be highly polymorphic in nature. It metabolizes several …
nervous system. It is known to be highly polymorphic in nature. It metabolizes several …
Characterizing and quantifying extrahepatic metabolism of (−)-Δ9-tetrahydrocannabinol (THC) and its psychoactive metabolite,(±)-11-hydroxy-Δ9-THC (11-OH-THC)
AR Kumar, GI Patilea-Vrana, O Anoshchenko… - Drug metabolism and …, 2022 - ASPET
(−)-Δ9-Tetrahydrocannabinol (THC) is the psychoactive constituent of cannabis, a drug
recreationally consumed orally or by inhalation. Physiologically based pharmacokinetic …
recreationally consumed orally or by inhalation. Physiologically based pharmacokinetic …
Development and Verification of a Linked Δ9-THC/11-OH-THC Physiologically Based Pharmacokinetic Model in Healthy, Nonpregnant Population and Extrapolation …
GI Patilea-Vrana, JD Unadkat - Drug Metabolism and Disposition, 2021 - ASPET
Conducting clinical trials to understand the exposure risk/benefit relationship of cannabis
use is not always feasible. Alternatively, physiologically based pharmacokinetic (PBPK) …
use is not always feasible. Alternatively, physiologically based pharmacokinetic (PBPK) …
Estimation of fetal-to-maternal unbound steady-state plasma concentration ratio of P-glycoprotein and/or breast cancer resistance protein substrate drugs using a …
Pregnant women are frequently prescribed drugs to treat chronic diseases such as human
immunodeficiency virus infection, but little is known about the benefits and risks of these …
immunodeficiency virus infection, but little is known about the benefits and risks of these …
Quantifying hepatic enzyme kinetics of (-)-∆ 9-Tetrahydrocannabinol (THC) and its psychoactive metabolite, 11-OH-THC, through in vitro modeling
GI Patilea-Vrana, JD Unadkat - Drug Metabolism and Disposition, 2019 - ASPET
The prevalence of cannabis use and the concentrations of the psychoactive cannabinoid in
cannabis,(-)-∆ 9-tetrahydrocannabinol (THC), are rising. Physiologically based …
cannabis,(-)-∆ 9-tetrahydrocannabinol (THC), are rising. Physiologically based …
Investigating Sex and Gender Influences on the Use and Effects of Cannabis
M Wright - 2023 - search.proquest.com
Sex and gender differences have been demonstrated in the use, harms, and effects of
cannabis and in cannabis use disorder. However, research investigating these differences is …
cannabis and in cannabis use disorder. However, research investigating these differences is …
Characterizing the Neurological Bioactivity of Cannabis Phytochemicals
JS Laws - 2024 - digital.library.adelaide.edu.au
Amyloid β (Aβ) aggregation and its associated neurotoxicity are the leading pathological
hallmarks of Alzheimer's disease (AD), resulting in oxidative stress and neuronal death …
hallmarks of Alzheimer's disease (AD), resulting in oxidative stress and neuronal death …