Will SARS-CoV-2 infection elicit long-lasting protective or sterilising immunity? Implications for vaccine strategies (2020)
DS Kim, S Rowland-Jones… - Frontiers in …, 2020 - frontiersin.org
In December 2019, an outbreak of a novel coronavirus (SARS-CoV-2) in Wuhan, China
resulted in the current COVID-19 global pandemic. The human immune system has not …
resulted in the current COVID-19 global pandemic. The human immune system has not …
MAIT cell activation and dynamics associated with COVID-19 disease severity
T Parrot, JB Gorin, A Ponzetta, KT Maleki… - Science …, 2020 - science.org
Severe COVID-19 is characterized by excessive inflammation of the lower airways. The
balance of protective versus pathological immune responses in COVID-19 is incompletely …
balance of protective versus pathological immune responses in COVID-19 is incompletely …
Emerging role for MAIT cells in control of antimicrobial resistance
Antimicrobial resistance is a serious threat to global public health as antibiotics are losing
effectiveness due to rapid development of resistance. The human immune system facilitates …
effectiveness due to rapid development of resistance. The human immune system facilitates …
Mucosal-associated invariant T (MAIT) cells are highly activated and functionally impaired in COVID-19 patients
S Deschler, J Kager, J Erber, L Fricke, P Koyumdzhieva… - Viruses, 2021 - mdpi.com
Coronavirus disease 2019 (COVID-19), caused by infection with severe acute respiratory
syndrome coronavirus 2 (SARS-CoV-2), comprises mild courses of disease as well as …
syndrome coronavirus 2 (SARS-CoV-2), comprises mild courses of disease as well as …
Mucosal-associated invariant T cell responses differ by sex in COVID-19
Background Sexual dimorphisms in immune responses contribute to coronavirus disease
2019 (COVID-19) outcomes, but the mechanisms governing this disparity remain …
2019 (COVID-19) outcomes, but the mechanisms governing this disparity remain …
[HTML][HTML] COVID-19 severity and obesity: are MAIT cells a factor?
People with obesity have an increased risk of severe COVID-19: a meta-analysis by Popkin
and colleagues1 found that the odds ratio of people with obesity being hospitalised with …
and colleagues1 found that the odds ratio of people with obesity being hospitalised with …
Biological functions of MAIT cells in tissues
Mucosal associated invariant T (MAIT) cells have a recognised innate-like capacity for
antibacterial host defence, consequent on the specificity of their T cell receptor (TCR) for …
antibacterial host defence, consequent on the specificity of their T cell receptor (TCR) for …
MR1-restricted T cells with MAIT-like characteristics are functionally conserved in the pteropid bat pteropus alecto
E Leeansyah, YY Hey, WR Sia, JHJ Ng, MY Gulam… - Iscience, 2020 - cell.com
Bats are reservoirs for a large number of viruses which have potential to cause major human
disease outbreaks, including the current coronavirus disease 2019 (COVID-19) pandemic …
disease outbreaks, including the current coronavirus disease 2019 (COVID-19) pandemic …
Human MAIT Cells Respond to Staphylococcus aureus with Enhanced Anti-Bacterial Activity
AJR Cooper, J Clegg, FC Cassidy, AE Hogan… - Microorganisms, 2022 - mdpi.com
Mucosal-Associated Invariant T (MAIT) cells have been shown to play protective roles during
infection with diverse pathogens through their propensity for rapid innate-like cytokine …
infection with diverse pathogens through their propensity for rapid innate-like cytokine …
IL-18-dependent MAIT cell activation in COVID-19
E Gea-Mallorquí - Nature Reviews Immunology, 2020 - nature.com
immunity. For example, MPPs had regions of higher chromatin accessibility near the
promoters of genes that regulate key cytokines such as TNF and Il-6, and transcriptomic and …
promoters of genes that regulate key cytokines such as TNF and Il-6, and transcriptomic and …