Understanding the dose–concentration–effect relationship is a fundamental component of
clinical pharmacology. Interpreting data arising from observations of this relationship …

Sepsis remains a major cause of mortality and morbidity in neonates, and, as a
consequence, antibiotics are the most frequently prescribed drugs in this vulnerable patient …

In order to improve the efficacy and safety of treatments, drug dosage needs to be adjusted
to the actual needs of each patient in a truly personalized medicine approach. Key for …

Abstract Background and Objectives Uncertainty exists regarding the optimal dosing
regimen for vancomycin in different patient populations, leading to a plethora of subgroup …

Objective Acute exacerbations of biofilm-associated Pseudomonas aeruginosa infections in
cystic fibrosis (CF) have limited treatment options. Ceftolozane/tazobactam (alone and with a …

Microbial cells embedded in a self-produced extracellular biofilm matrix cause chronic
infections, eg by Pseudomonas aeruginosa in the lungs of cystic fibrosis patients. The …

Background: Although aminoglycosides are often used as treatment for Gram-negative
infections, optimal dosing regimens remain unclear, especially in ICU patients. This is due to …

Background Cystic fibrosis is a lethal inherited disease that affects multiple organs. To
provide optimal pharmacological treatment of comorbidities associated with cystic fibrosis …

Hypermutable Pseudomonas aeruginosa strains are prevalent in patients with cystic fibrosis
and rapidly become resistant to antibiotic monotherapies. Combination dosage regimens …

This is a PROSPERO registered systematic review (CRD42018105207), conducted to
summarize the available knowledge regarding the population pharmacokinetics of digoxin …