The role of placental hormones in mediating maternal adaptations to support pregnancy and lactation

T Napso, HEJ Yong, J Lopez-Tello… - Frontiers in …, 2018 - frontiersin.org
During pregnancy, the mother must adapt her body systems to support nutrient and oxygen
supply for growth of the baby in utero and during the subsequent lactation. These include …

Melatonin membrane receptors in peripheral tissues: distribution and functions

RM Slominski, RJ Reiter… - Molecular and cellular …, 2012 - Elsevier
Many of melatonin's actions are mediated through interaction with the G-protein coupled
membrane bound melatonin receptors type 1 and type 2 (MT1 and MT2, respectively) or …

Melatonin receptors in humans: biological role and clinical relevance

C Ekmekcioglu - Biomedicine & Pharmacotherapy, 2006 - Elsevier
In addition to its antioxidative effects melatonin acts through specific nuclear and plasma
membrane receptors. To date, two G-protein coupled melatonin membrane receptors, MT1 …

Riding the rhythm of melatonin through pregnancy to deliver on time

R McCarthy, ES Jungheim, JC Fay, K Bates… - Frontiers in …, 2019 - frontiersin.org
Pregnancy is influenced by the circadian (“circa” or approximately; diēm or day) system,
which coordinates physiology and behavior with predictable daily changes in the …

Circadian rhythms in colonic function

TJ Hibberd, S Ramsay, P Spencer-Merris… - Frontiers in …, 2023 - frontiersin.org
A rhythmic expression of clock genes occurs within the cells of multiple organs and tissues
throughout the body, termed “peripheral clocks.” Peripheral clocks are subject to …

Maternal effects in mammals: broadening our understanding of offspring programming

PD Edwards, SG Lavergne, LK McCaw… - Frontiers in …, 2021 - Elsevier
The perinatal period is a sensitive time in mammalian development that can have long-
lasting consequences on offspring phenotype via maternal effects. Maternal effects have …

The human myometrium as a target for melatonin

N Schlabritz-Loutsevitch, N Hellner… - The Journal of …, 2003 - academic.oup.com
The circadian timing of spontaneous human deliveries results in births occurring statistically
more often during the nocturnal phase of the 24-h cycle. The neuroendocrine mechanisms …

Protective effects of melatonin against formaldehyde-induced oxidative damage and apoptosis in rat testes: an immunohistochemical and biochemical study

OA Ozen, MA Kus, I Kus, OA Alkoc… - Systems Biology in …, 2008 - Taylor & Francis
This study investigated the protective effects of melatonin against formaldehyde-induced
oxidative damage and apoptosis in rat testes. A total of 21 male Wistar rats were divided into …

Adjuvant use of melatonin for pain management in dysmenorrhea—A randomized double-blinded, placebo-controlled trial

L Söderman, M Edlund, Y Böttiger… - European journal of clinical …, 2022 - Springer
Purpose Dysmenorrhea is a common, recurring, painful condition with a global prevalence
of 71%. The treatment regime for dysmenorrhea includes hormonal therapies and NSAID …

Protective effects of melatonin against carbon tetrachloride‐induced hepatotoxicity in rats: a light microscopic and biochemical study

I Kus, M Ogeturk, H Oner, S Sahin… - … biochemistry and its …, 2005 - Wiley Online Library
The aim of this study was to examine the protective effects of melatonin against CCl4‐
induced hepatotoxicity in the rat. Twenty‐four male Wistar rats were divided into three …