Induced pluripotent stem cell (iPSC) technologies have provided in vitro models of
inaccessible human cell types, yielding new insights into disease mechanisms especially for …

Significance: Our current knowledge of the pathophysiology and molecular mechanisms
causing psychiatric disorders is modest, but genetic susceptibility and environmental factors …

Noncoding genetic variation is a major driver of phenotypic diversity, but functional
interpretation is challenging. To better understand common genetic variation associated with …

Aberrant induction of type I IFN is a hallmark of the inherited encephalopathy Aicardi-
Goutières syndrome (AGS), but the mechanisms triggering disease in the human central …

New methods for investigating human astrocytes are urgently needed, given their critical
role in the central nervous system. Here we show that CD49f is a novel marker for human …

The glial environment influences neurological disease progression, yet much of our
knowledge still relies on preclinical animal studies, especially regarding astrocyte …

The mechanistic basis of gliogenesis, which occurs late in human development, is poorly
understood. Here we identify nuclear factor IA (NFIA) as a molecular switch inducing human …

Astrocyte reactivation has been discovered to be an important contributor to several
neurological diseases. In vitro models involving human astrocytes have the potential to …

Recent studies highlighted the importance of astrocytes in neuroinflammatory diseases,
interacting closely with other CNS cells but also with the immune system. However, due to …

The central goal of regenerative medicine is to replace damaged or diseased tissue with
cells that integrate and function optimally. The capacity of pluripotent stem cells to produce …