T helper type 17 (Th17) cells and pTreg cells, which share a common precursor cell (the
naïve CD4 T cell), require a common tumor growth factor (TGF)-β signal for initial …

The remarkable T cell receptor (TCR) performs essential functions in the initiation of
intracellular signals required for T cell development, repertoire selection and effector …

Protein ubiquitination is a dynamic multifaceted post-translational modification involved in
nearly all aspects of eukaryotic biology. Once attached to a substrate, the 76-amino acid …

The master pro-inflammatory cytokine, tumour necrosis factor (TNF), has been shown to
modulate multiple signalling pathways, with wide-ranging downstream effects. TNF plays a …

Regulatory T cells (TReg cells), a specialized T cell lineage, have a pivotal function in the
control of self tolerance and inflammatory responses. Recent studies have revealed a …

Summary Methionine-1 (M1)-linked ubiquitin chains regulate the activity of NF-κB, immune
homeostasis, and responses to infection. The importance of negative regulators of M1-linked …

Ubc13-catalyzed K63 ubiquitination is a major control point for immune signaling. Recent
evidence has shown that the control of multiple immune functions, including chronic …

To obtain a molecular definition of regulatory T (Treg) cell identity, we performed proteomics
and transcriptomics on various populations of human regulatory and conventional CD4+ T …

Regulatory T (Treg) cells are essential for maintaining immune homeostasis and tolerance,
but the mechanisms regulating the stability and function of Treg cells have not been fully …

Clinical trials are evaluating the efficacy of anti-TIGIT for use as single-agent therapy or in
combination with programmed death 1 (PD-1)/programmed death-ligand 1 blockade. How …