Emerging roles of RNA methylation in development

MK Wang, CC Gao, YG Yang - Accounts of Chemical Research, 2023 - ACS Publications
Conspectus More than 170 different types of chemical modifications have been identified on
diverse types of RNA, collectively known as the epitranscriptome. Among them, N 6 …

Roles of RNA methylations in cancer progression, autophagy, and anticancer drug resistance

H Jo, K Shim, D Jeoung - International Journal of Molecular Sciences, 2023 - mdpi.com
RNA methylations play critical roles in RNA processes, including RNA splicing, nuclear
export, nonsense-mediated RNA decay, and translation. Regulators of RNA methylations …

METTL3-regulated m6A modification impairs the decidualization of endometrial stromal cells by regulating YTHDF2-mediated degradation of FOXO1 mRNA in …

X Li, J Jin, X Long, R Weng, W Xiong, J Liang… - Reproductive Biology …, 2023 - Springer
Background Endometriosis-related infertility is a common worldwide reproductive health
concern. Despite ongoing research, the causes of infertility remain unclear. Evidence …

RNA N6-methyladenosine modification in female reproductive biology and pathophysiology

E Huang, L Chen - Cell Communication and Signaling, 2023 - Springer
Gene expression and posttranscriptional regulation can be strongly influenced by epigenetic
modifications. N6-methyladenosine, the most extensive RNA modification, has been …

Melatonin promotes progesterone secretion in sheep luteal cells by regulating autophagy via the AMPK/mTOR pathway

H Duan, S Yang, L Xiao, S Yang, Z Yan, F Wang, X Ma… - Theriogenology, 2024 - Elsevier
The corpus luteum is primarily responsible for the production and secretion of progesterone.
Melatonin has been established to regulate autophagy and induce progesterone secretion …

Aberrant activation of estrogen receptor‐α signaling in Mettl14‐deficient uteri impairs embryo implantation

R Kobayashi, R Kawabata‐Iwakawa… - The FASEB …, 2023 - Wiley Online Library
The precise control of endometrial receptivity is crucial for successful embryo implantation,
which is strictly regulated by the ovarian steroid hormones estrogen and progesterone …

[HTML][HTML] Role and mechanism of epigenetic regulation in the aging of germ cells: prospects for targeted interventions

XC Huang, YN Jiang, HJ Bao, JL Wang… - Aging and …, 2024 - pmc.ncbi.nlm.nih.gov
In modern times, a notable trend toward delayed childbearing has been observed in most
developed countries. As a result, sperm aging and quality loss, as well as premature ovarian …

The role of m6A-associated membraneless organelles in the RNA metabolism processes and human diseases

F Bu, H Wang, C Xu, K Song, Z Dai, L Wang… - …, 2024 - pmc.ncbi.nlm.nih.gov
N6-methyladenosine (m6A) is the most abundant post-transcriptional dynamic RNA
modification process in eukaryotes, extensively implicated in cellular growth, embryonic …

The landscape of implantation and placentation: deciphering the function of dynamic RNA methylation at the maternal-fetal interface

S Wu, H Xie, Y Su, X Jia, Y Mi, Y Jia… - Frontiers in …, 2023 - frontiersin.org
The maternal-fetal interface is defined as the interface between maternal tissue and sections
of the fetus in close contact. RNA methylation modifications are the most frequent kind of …

YTHDF1 shapes “cold” tumor and inhibits CD8+ T cells infiltration and function in breast cancer

L Jing, K Zhou, Z Wang, Y Li, Y Fan, T Liu… - Experimental Cell …, 2023 - Elsevier
Abstract While YTH N 6-methyladenosine RNA binding protein 1 (YTHDF1) was recognized
as a crucial contributor in the development and immune-related regulation of various types …