Regulation of placental development and its impact on fetal growth—new insights from mouse models

L Woods, V Perez-Garcia, M Hemberger - Frontiers in endocrinology, 2018 - frontiersin.org
The placenta is the chief regulator of nutrient supply to the growing embryo during gestation.
As such, adequate placental function is instrumental for developmental progression …

Pregnancy‐induced changes in β‐cell function: what are the key players?

ER Salazar‐Petres… - The Journal of …, 2022 - Wiley Online Library
Maternal metabolic adaptations during pregnancy ensure appropriate nutrient supply to the
developing fetus. This is facilitated by reductions in maternal peripheral insulin sensitivity …

A nutrient-sensing transition at birth triggers glucose-responsive insulin secretion

A Helman, AL Cangelosi, JC Davis, Q Pham… - Cell metabolism, 2020 - cell.com
A drastic transition at birth, from constant maternal nutrient supply in utero to intermittent
postnatal feeding, requires changes in the metabolic system of the neonate. Despite their …

The maternal microbiome promotes placental development in mice

GN Pronovost, KB Yu, EJL Coley-O'Rourke… - Science …, 2023 - science.org
The maternal microbiome is an important regulator of gestational health, but how it affects
the placenta as the interface between mother and fetus remains unexplored. Here, we show …

What determines organ size during development and regeneration?

L Boulan, P Léopold - Development, 2021 - journals.biologists.com
The sizes of living organisms span over 20 orders of magnitude or so. This daunting
observation could intimidate researchers aiming to understand the general mechanisms …

Congenital Zika syndrome is associated with maternal protein malnutrition

J Barbeito-Andrés, P Pezzuto, LM Higa, AA Dias… - Science …, 2020 - science.org
Zika virus (ZIKV) infection during pregnancy is associated with a spectrum of developmental
impairments known as congenital Zika syndrome (CZS). The prevalence of this syndrome …

Maternal macronutrient consumption and the developmental origins of metabolic disease in the offspring

SM Kereliuk, GM Brawerman, VW Dolinsky - International Journal of …, 2017 - mdpi.com
Recent research aimed at understanding the rise in obesity and cardiometabolic disease in
children suggests that suboptimal maternal nutrition conditions organ systems and …

Alterations in placental glycogen deposition in complicated pregnancies: Current preclinical and clinical evidence

LK Akison, MD Nitert, VL Clifton, KM Moritz… - Placenta, 2017 - Elsevier
Normal placental function is essential for optimal fetal growth. Transport of glucose from
mother to fetus is critical for fetal nutrient demands and can be stored in the placenta as …

Placental glycogen stores and fetal growth: insights from genetic mouse models

SJ Tunster, ED Watson, AL Fowden… - Reproduction, 2020 - rep.bioscientifica.com
The placenta performs a range of crucial functions that support fetal growth during
pregnancy, including facilitating the supply of oxygen and nutrients to the fetus, removal of …

Integration and the developmental genetics of allometry

B Hallgrímsson, DC Katz, JD Aponte… - Integrative and …, 2019 - academic.oup.com
Allometry refers to the ways in which organismal shape is associated with size. It is a special
case of integration, or the tendency for traits to covary, in that variation in size is ubiquitous …