CD74 is a type II cell surface receptor found to be highly expressed in several hematological
and solid cancers, due to its ability to activate pathways associated with tumor cell survival …

Acute lymphoblastic leukemia (ALL) with fusions of ABL-class tyrosine kinase genes other
than BCR:: ABL1 occurs in∼ 3% of children with ALL. The tyrosine kinase genes involved in …

T-cell acute lymphoblastic leukemia (T-ALL) and T-cell lymphoblastic lymphoma (T-LBL) are
rare aggressive hematologic malignancies. Current treatment consists of intensive …

Philadelphia chromosome (Ph)-like acute lymphoblastic leukemia (ALL) is a subset of ALL
that demonstrated a high treatment failure rate. One of the hallmarks of Ph-like ALL is …

ABSTRACT Philadelphia-like (Ph-like) or BCR:: ABL1-like acute lymphoblastic leukemia
(ALL) is a common high-risk subtype of B-cell precursor ALL (B-ALL) characterized by a …

Patients with Philadelphia chromosome‐like acute lymphoblastic leukaemia (Ph‐like ALL)
often face a grim prognosis, with PDGFRB gene fusions being commonly detected in this …

Despite the increasing availability of comprehensive next generation sequencing (NGS), its
role in characterizing pediatric hematologic malignancies remains undefined. We describe …

Platelet-derived growth factor receptor beta (PDGFRβ), a type III receptor tyrosine kinase
(RTK) with a featured kinase insert, regulates important cellular functions. Dysregulation of …