Ceramides are a heterogeneous group of bioactive membrane sphingolipids that play
specialized regulatory roles in cellular metabolism depending on their characteristic fatty …

Insulin resistance and muscle mass loss often coincide in individuals with type 2 diabetes.
Most patients with type 2 diabetes are overweight, and it is well established that obesity and …

Excessive levels of saturated fatty acids are toxic to cells, although the basis for this
lipotoxicity remains incompletely understood. Here, we analyzed the transcriptome …

The endoplasmic reticulum (ER) is a critical site of protein, lipid, and glucose metabolism,
lipoprotein secretion, and calcium homeostasis. Many of the sensing, metabolizing, and …

Dyslipidemia is a common nutritional and metabolic disorder in patients with chronic kidney
disease. Accumulating evidence supports the hypothesis that prolonged metabolic …

The steady rise in Western obesity rates has been closely linked to significant increases in a
multitude of accompanying health problems including non-alcoholic fatty liver disease …

Ceramide accumulation is a hallmark in the manifestation of numerous obesity-related
diseases, such as type 2 diabetes mellitus and atherosclerosis. Until the early 2000s …

The dramatic increase in the prevalence of obesity and its strong association with
cardiovascular disease have resulted in unprecedented interest in understanding the effects …

Non-alcoholic fatty liver disease (NAFLD) is the most common form of liver disease and
leading cause of cirrhosis in the United States and developed countries. NAFLD is closely …

Obesity and metabolic disorders such as type 2 diabetes mellitus are accompanied by
increased lipid deposition in adipose and non-adipose tissues including liver, pancreas …