Adenosine-metabolizing enzymes, adenosine kinase and adenosine deaminase, in cancer
G Zhulai, E Oleinik, M Shibaev, K Ignatev - Biomolecules, 2022 - mdpi.com
The immunosuppressive effect of adenosine in the microenvironment of a tumor is well
established. Presently, researchers are developing approaches in immune therapy that …
established. Presently, researchers are developing approaches in immune therapy that …
Challenges in dengue vaccines development: pre-existing infections and cross-reactivity
AM Izmirly, SO Alturki, SO Alturki, J Connors… - Frontiers in …, 2020 - frontiersin.org
Dengue is one of the most frequently transmitted mosquito-borne diseases in the world,
which creates a significant public health concern globally, especially in tropical and …
which creates a significant public health concern globally, especially in tropical and …
Human T follicular helper clones seed the germinal center–resident regulatory pool
The mechanisms by which FOXP3+ T follicular regulatory (Tfr) cells simultaneously steer
antibody formation toward microbe or vaccine recognition and away from self-reactivity …
antibody formation toward microbe or vaccine recognition and away from self-reactivity …
Purinergic modulation of the immune response to infections
N Eberhardt, G Bergero, YL Mazzocco Mariotta… - Purinergic …, 2022 - Springer
Infectious diseases are caused by the invasion of pathogenic microorganisms such as fungi,
bacteria, viruses, and parasites. After infection, disease progression relies on the complex …
bacteria, viruses, and parasites. After infection, disease progression relies on the complex …
Adenosine deaminase inhibition
Adenosine deaminase is a critical enzyme in purine metabolism that regulates intra and
extracellular adenosine concentrations by converting it to inosine. Adenosine is an important …
extracellular adenosine concentrations by converting it to inosine. Adenosine is an important …
Possible role of adenosine in COVID-19 pathogenesis and therapeutic opportunities
The outbreak of the novel coronavirus disease 2019 (COVID-19) caused by Severe Acute
Respiratory Syndrome CoronaVirus-2 (SARS-CoV-2) requires urgent clinical interventions …
Respiratory Syndrome CoronaVirus-2 (SARS-CoV-2) requires urgent clinical interventions …
Therapeutic perspectives of adenosine deaminase inhibition in cardiovascular diseases
B Kutryb-Zajac, P Mierzejewska, EM Slominska… - Molecules, 2020 - mdpi.com
Adenosine deaminase (ADA) is an enzyme of purine metabolism that irreversibly converts
adenosine to inosine or 2′ deoxyadenosine to 2′ deoxyinosine. ADA is active both inside …
adenosine to inosine or 2′ deoxyadenosine to 2′ deoxyinosine. ADA is active both inside …
A follicular regulatory Innate Lymphoid Cell population impairs interactions between germinal center Tfh and B cells
Abstract Innate Lymphoid Cells (ILCs) are immune cells typically found on mucosal surfaces
and in secondary lymphoid organs where they regulate the immune response to pathogens …
and in secondary lymphoid organs where they regulate the immune response to pathogens …
Changes in adenosine deaminase activity and endothelial dysfunction after mild coronavirus disease-2019
A Jedrzejewska, A Kawecka, A Braczko… - International journal of …, 2023 - mdpi.com
Endothelial cells are a preferential target for SARS-CoV-2 infection. Previously, we have
reported that vascular adenosine deaminase 1 (ADA1) may serve as a biomarker of …
reported that vascular adenosine deaminase 1 (ADA1) may serve as a biomarker of …
Adenosine deaminase augments SARS-CoV-2 specific cellular and humoral responses in aged mouse models of immunization and challenge
Despite numerous clinically available vaccines and therapeutics, aged patients remain at
increased risk for COVID-19 morbidity. Furthermore, various patient populations, including …
increased risk for COVID-19 morbidity. Furthermore, various patient populations, including …