Schwann cells (SCs) are fundamental components of the peripheral nervous system (PNS)
of all vertebrates and play essential roles in development, maintenance, function, and …

Peripheral nerves and Schwann cells have to sustain constant mechanical constraints,
caused by developmental growth as well as stretches associated with movements of the …

Initially identified in Drosophila, the Hippo signaling pathway regulates how cells respond to
their environment by controlling proliferation, migration and differentiation. Many recent …

YAP and TAZ are effectors of the Hippo pathway that controls multicellular development by
integrating chemical and mechanical signals. Peripheral nervous system development …

Peripheral nerves are organized into discrete compartments. Axons, Schwann cells (SCs),
and endoneurial fibroblasts (EFs) reside within the endoneurium and are surrounded by the …

Myelinating cells are sensitive to mechanical stimuli from their extracellular matrix. Ablation
of YAP and TAZ mechanotransducers in Schwann cells abolishes the axon–Schwann cell …

In order for our complex nervous system to develop normally, both precise spatial and
temporal regulation of a number of different signaling pathways is critical. During both early …

It is well established that axonal Neuregulin 1 type 3 (NRG1t3) regulates developmental
myelin formation as well as EGR2‐dependent gene activation and lipid synthesis. However …

Background Numerous studies have indicated that myelination is the result of the interplay
between extracellular signals and an intricate network of transcription factors. Yet, the …

Purine-rich element binding protein B (Purβ) is a single-stranded DNA (ssDNA) and RNA-
binding protein that functions as a transcriptional repressor of genes encoding certain …