The function of antibodies (Abs) involves specific binding to antigens (Ags) and activation of
other components of the immune system to fight pathogens. The six hypervariable loops …

Tuberculosis (TB) is an infectious disease caused by Mycobacterium tuberculosis. As a
result of the coronavirus disease 2019 (COVID-19) pandemic, the global TB mortality rate in …

The interaction between antibodies and antigens is one of the most important immune
system mechanisms for clearing infectious organisms from the host. Antibodies bind to …

Monoclonal antibodies are playing an increasing role in both human and animal health.
Different strategies of protein and chemical engineering, including humanization techniques …

Recent clinical trials using antibodies with low toxicity and high efficiency have raised
expectations for the development of next-generation protein therapeutics. However, the …

The ability to identify antigenic determinants of pathogens, or epitopes, is fundamental to
guide rational vaccine development and immunotherapies, which are particularly relevant …

The concept of antibody specificity is analyzed and shown to reside in the ability of an
antibody to discriminate between two antigens. Initially antibody specificity was attributed to …

Background Accurate prediction of antigenic epitopes is important for immunologic research
and medical applications, but it is still an open problem in bioinformatics. The case for …

The majority of biological processes are mediated via protein–protein interactions.
Determination of residues participating in such interactions improves our understanding of …

Abstract SARS-CoV-2, which causes COVID-19, was first identified in humans in late 2019
and is a coronavirus which is zoonotic in origin. As it spread around the world there has …