A review and database of snake venom proteomes

T Tasoulis, GK Isbister - Toxins, 2017 - mdpi.com
Advances in the last decade combining transcriptomics with established proteomics
methods have made possible rapid identification and quantification of protein families in …

The search for natural and synthetic inhibitors that would complement antivenoms as therapeutics for snakebite envenoming

JM Gutiérrez, LO Albulescu, RH Clare, NR Casewell… - Toxins, 2021 - mdpi.com
A global strategy, under the coordination of the World Health Organization, is being unfolded
to reduce the impact of snakebite envenoming. One of the pillars of this strategy is to ensure …

[PDF][PDF] Antivenomics and its role in enhancing cobra envenomation treatments: A review of current practices and future prospects

I Karunarathna, K De Alvis, P Gunasena… - 2024 - researchgate.net
The King Cobra (Ophiophagus hannah) holds cultural significance and is one of the most
medically important venomous snakes worldwide. Envenomation by King Cobras often …

[PDF][PDF] Innovative approaches to neutralizing cobra venom: Advances in antivenomics and recombinant antivenoms

I Karunarathna, K De Alvis, P Gunasena… - 2024 - researchgate.net
The King Cobra (Ophiophagus hannah) holds cultural significance and is one of the most
medically important venomous snakes worldwide. Envenomation by King Cobras often …

Convergent evolution of pain-inducing defensive venom components in spitting cobras

TD Kazandjian, D Petras, SD Robinson, J van Thiel… - Science, 2021 - science.org
Convergent evolution provides insights into the selective drivers underlying evolutionary
change. Snake venoms, with a direct genetic basis and clearly defined functional …

Biogeographic venom variation in Russell's viper (Daboia russelii) and the preclinical inefficacy of antivenom therapy in snakebite hotspots

RR Senji Laxme, S Khochare, S Attarde… - PLoS neglected …, 2021 - journals.plos.org
Background Snakebite in India results in over 58,000 fatalities and a vast number of
morbidities annually. The majority of these clinically severe envenomings are attributed to …

Biogeographical venom variation in the Indian spectacled cobra (Naja naja) underscores the pressing need for pan-India efficacious snakebite therapy

RR Senji Laxme, S Attarde, S Khochare… - PLOS neglected …, 2021 - journals.plos.org
Background Snake venom composition is dictated by various ecological and environmental
factors, and can exhibit dramatic variation across geographically disparate populations of …

In vitro discovery of a human monoclonal antibody that neutralizes lethality of cobra snake venom

L Ledsgaard, AH Laustsen, U Pus, J Wade, P Villar… - MAbs, 2022 - Taylor & Francis
The monocled cobra (Naja kaouthia) is among the most feared snakes in Southeast Asia
due to its toxicity, which is predominantly derived from long-chain α-neurotoxins. The only …

In vivo neutralization of dendrotoxin-mediated neurotoxicity of black mamba venom by oligoclonal human IgG antibodies

AH Laustsen, A Karatt-Vellatt, EW Masters… - Nature …, 2018 - nature.com
The black mamba (Dendroaspis polylepis) is one of the most feared snake species of the
African savanna. It has a potent, fast-acting neurotoxic venom comprised of dendrotoxins …

Snake venomics: fundamentals, recent updates, and a look to the next decade

CH Tan - Toxins, 2022 - mdpi.com
Venomic research, powered by techniques adapted from proteomics, transcriptomics, and
genomics, seeks to unravel the diversity and complexity of venom through which knowledge …